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A More Physiological Feeding Process in ICU:the Intermittent Infusion With Semi-solidification of Nutrients
NA trial testing semi-solid agent with standard enteral feeding in Nutrition, Enteral in 40 participants. Completed in 1 March 2017.
| Lead sponsor | Second Affiliated Hospital, School of Medicine, Zhejiang University |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | prevention |
| Enrollment | 40 |
| Start date | 1 June 2016 |
| Primary completion | 1 March 2017 |
| Estimated completion | 1 March 2017 |
| Sites | 1 location across China |
Second Affiliated Hospital, School of Medicine, Zhejiang University
Adults 14 to 90, any sex, with Nutrition, Enteral. Patients with the condition only — healthy volunteers not accepted.
Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.
the ratio of the enteral nutrition=administered volume of enteral nutrition / prescribed volume of nutrition X 100%; This ratio fluctuates between 0 and 100%, and the higher the ratio, the higher the execution rate
| Group | Value | 95% CI |
|---|---|---|
| Intermittent Feeding With Semi-solid Nutrients | 0.98 | ± 0.067 |
| Standard Enteral Feeding | 0.73 | ± 0.15 |
the definition of FI was included one of the conditions:diarrhea, vomiting, regurgitation, obvious bowel distension and GRV\>200mL. Due to the small sample size, only the number of patients who occurred was recorded.
| Group | Value | 95% CI |
|---|---|---|
| Intermittent Feeding | 8 | |
| Intermittent Feeding With Semi-solid Nutrients | 2 |
patient contain the following three conditions: 1.Sputum volume increased or Sputum properties change;2.CT Scan-Chest suggest that there was lung infection; 3.CRP and / or PCT increased
| Group | Value | 95% CI |
|---|---|---|
| Intermittent Feeding | 8 | |
| Intermittent Feeding With Semi-solid Nutrients | 7 |
dead within 30 days in ICU
| Group | Value | 95% CI |
|---|---|---|
| Intermittent Feeding With Semi-solid Nutrients | 3 | |
| Intermittent Feeding | 2 |
| Group | Value | 95% CI |
|---|---|---|
| Intermittent Feeding With Semi-solid Nutrients | 11 | |
| Intermittent Feeding | 12 |
Divided into three grades:I:GV less than 4mmol/24h; II 4-6mmol/24h;III more than 6mmol/24h
| Group | Value | 95% CI |
|---|---|---|
| Intermittent Feeding With Semi-solid Nutrients | 7.514 | ± 2.2309 |
| Intermittent Feeding | 8.457 | ± 2.9456 |
| Group | Value | 95% CI |
|---|---|---|
| Intermittent Feeding With Semi-solid Nutrients | 8.336 | ± 2.1653 |
| Intermittent Feeding | 9.700 | ± 3.1001 |
| Group | Value | 95% CI |
|---|---|---|
| Intermittent Feeding With Semi-solid Nutrients | 9.229 | ± 3.2587 |
| Intermittent Feeding | 9.664 | ± 3.1023 |
| Group | Value | 95% CI |
|---|---|---|
| Intermittent Feeding With Semi-solid Nutrients | 9.342857 | ± 3.1353357 |
| Intermittent Feeding | 8.985714 | ± 3.2846630 |
| Group | Value | 95% CI |
|---|---|---|
| Intermittent Feeding With Semi-solid Nutrients | 8.635714 | ± 2.4069154 |
| Intermittent Feeding | 8.992857 | ± 3.1086639 |
| Group | Value | 95% CI |
|---|---|---|
| Intermittent Feeding With Semi-solid Nutrients | 8.064286 | ± 1.9727400 |
| Intermittent Feeding | 8.721429 | ± 2.5137097 |
| Group | Value | 95% CI |
|---|---|---|
| Intermittent Feeding With Semi-solid Nutrients | 8.436 | ± 2.2016 |
| Intermittent Feeding | 8.686 | ± 2.9493 |
| Group | Value | 95% CI |
|---|---|---|
| Intermittent Feeding With Semi-solid Nutrients | 8.857 | ± 2.5687 |
| Intermittent Feeding | 9.450 | ± 3.1889 |
every participators stayed in hospital
| Group | Value | 95% CI |
|---|---|---|
| Intermittent Feeding With Semi-solid Nutrients | 20.07 | ± 25.71 |
| Intermittent Feeding | 14.36 | ± 7.59 |
Malnutrition and underfeeding are major challenges in caring for critically ill patients. Continuous feeding were thought to be better tolerated by patients with the limited absorptive gut surface area or gastrointestinal dysfunction, but associated with more tube clogging and required the patient to be attached to an infusion pump for significant periods of time. Intermittent infusion resembled more physiological feeding process, which allowed greater patient mobility and might reach goal enteral calories earlier, and the latter were considered to effectively decrease the length of stay (LOS)-in-hospital and mortality. However, it also had some previous study found that intermittent infusion had more complications, such as diarrhea, regurgitation than continuous. Some study found that it was an efficient way to prevent aspiration and reflux by increasing the enteral nutrient solution viscosity and improve bolus intermittent feeding intolerance. The primary goal of this was to study whether receiving semi-solidification of nutrients could increase the percent prescribed calories received by improving the feeding intolerance, and secondary goal was to observing the effect of semi-solid nutrient to the LOS of ICU and in-hospital, lung infection, 30-days mortality and the glycemic variability (GV).
2 peer-reviewed publications reference this trial (live from Europe PMC):
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