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NCT03012633: FILYTHO
Rapid Diagnostic of Hyperfibrinolysis in Liver Transplantation
trial testing Lysis timer in Liver Transplantation in 30 participants. Completed in 12 July 2017.
14 June 2017
Quick facts
| Lead sponsor | University Hospital, Bordeaux |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 30 |
| Start date | 9 January 2017 |
| Primary completion | 14 June 2017 |
| Estimated completion | 12 July 2017 |
| Sites | 1 location across France |
Drugs / interventions tested
- Lysis timer
Conditions studied
- Liver Transplantation — all drugs for Liver Transplantation →
Sponsor
University Hospital, Bordeaux
Who can join
18 and older, any sex, with Liver Transplantation. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
During liver transplantation (LT), hyperfibrinolysis is one of the most important modification of haemostasis. It is associated with t-PA and protein C increased activity. Hyperfibrinolysis is frequent, hardly predictable and associated with major bleeding. The diagnostic of hyperfibrinolysis with standard laboratory tests (euglobulin lysis test, t-PA, PAI-1 and D-dimers dosages) does not provide an answer in a delay compatible with the clinical practice in the operating room. The "Lysis Timer" is a device developed by Hyphen-Sysmex in collaboration with SD Innovation and Charleroi University Hospital (Belgium). It allows the implementation of the "Global Fibrinolytic Capacity", or GFC test, in a complete system associating i) the reagents for in vitro triggering of the clot and its lysis (contact system activators, t-PA, thrombin and calcium), ii) the signal acquisition by the Lysis Timer (able to convert the analogic signal of the absorbance modifications related to clot formation into a numeric signal) and iii) a dedicated software treating the numeric signal to define clot lysis time. The GFC test, using t-PA to shorten signal acquisition times, is particularly adapted to the diagnosis of hyperfibrinolysis with PAI-1 collapse, of which LT is an example.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Lysis Timer: a new sensitive tool to diagnose hyperfibrinolysis in liver transplantation.
Roullet S, Labrouche S, Mouton C, Quinart A, et al · · 2019 · cited 13× · PMID 30282673 · DOI 10.1136/jclinpath-2018-205280
Verify or expand the search:
- PubMed search for NCT03012633
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other University Hospital, Bordeaux trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT03012633 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Bordeaux
- Last refreshed: 17 May 2024
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