Who is sponsoring NCT02996539?

NCT02996539 is sponsored by Shi wei, MM.

What drugs are being tested in NCT02996539?

Interventions in NCT02996539: Clinical examination and laboratory measurements.

What condition does NCT02996539 study?

NCT02996539 studies Type2 Diabetes Mellitus.

Is NCT02996539 still recruiting?

NCT02996539 is currently completed. Last updated 14 December 2016.

Last reviewed 2016-12-14 · How we verify

NCT02996539

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Heart Rate Variability and Diabetic Kidney Disease in Type 2 Diabetes Mellitus Patients

Completed Last updated 14 December 2016

What this trial tests

trial testing Clinical examination and laboratory measurements in Type2 Diabetes Mellitus in 392 participants. Completed in 1 April 2015.

Timeline

1 February 2013

Primary endpoint
1 April 2015

1 April 2015

Quick facts

Lead sponsor	Shi wei, MM
Status	Completed
Study type	OBSERVATIONAL
Enrollment	392
Start date	1 February 2013
Primary completion	1 April 2015
Estimated completion	1 April 2015
Sites	1 location across China

Drugs / interventions tested

Clinical examination and laboratory measurements

Conditions studied

Type2 Diabetes Mellitus — all drugs for Type2 Diabetes Mellitus →

Sponsor

Shi wei, MM

Who can join

Adults 18 to 80, any sex, with Type2 Diabetes Mellitus. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Association between HRV and renal function (eGFR and UACR)
Time frame: 1week
Assessment of HRV HRV measurement based on 24-hour ambulatory ECG monitoring was obtained from all patients using a 3- channel digital Holter recorder (CB-2302-A, Wuxi, Jiangsu, China). Assessment of DKD DKD was defined as the presence of albuminuria (UACR ≥ 30 mg/g,urine albumin in milligram,creatinine in gram) or eGFR \< 60 mL/min/1.73 m\^2 (creatinine concentration in umol/l,creatinine molecula

Sponsor's own description

Several studies have investigated an association between cardiac autonomic neuropathy (CAN) and albuminuria, glomerular filtration rate, or both, and hypothesized that CAN is involved in the pathogenesis of nephropathy. However, most of these studies had focused on Caucasians and were limited to a small number of patients with type 1 diabetes mellitus, or had used a conventional Ewing battery of tests based on dynamic cardiovascular maneuvers.Yet, there is consistent data showing that Asian diabetic populations, including the Chinese, have a higher risk of renal complications than Caucasians do. The present study investigated an association between heart rate variability (HRV) parameters and diabetic kidney disease (DKD) in Chinese type 2 diabetes mellitus (T2DM) patients, specifically through time and frequency domain analyses of HRV and urine albumin creatinine ratio (UACR) or estimated glomerular filtration rate (eGFR).

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

Heart Rate Variability and Chronic Kidney Disease in Patients with Type 2 Diabetes.
Shi W, Zhang J, Chen D, Chen X, et al · · 2022 · cited 3× · PMID 35619730 · DOI 10.1155/2022/2475750

Verify or expand the search:

Other recruiting trials for Type2 Diabetes Mellitus

Currently open trials in the same condition.

NCT07533604 — SnapDandCGMinType2Diabetes · NA · recruiting
NCT06961019 — Clinical Study to Assess the Safety, Efficacy and In-Use Tolerability of Herbal-Based Sugar Support Effervescent Tablets · NA · recruiting
NCT06497842 — Effort During Resistance Training in Type 2 Diabetes · NA · active not recruiting
NCT06257966 — A Phase 3 Study to Evaluate the Efficacy of JY09 Compared With Dulaglutide in Combination Therapy Diabetes Mellitus Type · Phase 3 · active not recruiting
NCT03647306 — Behavioral Chronotype: Impact on Sleep and Metabolism · NA · active not recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02996539 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Shi wei, MM
Last refreshed: 14 December 2016

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02996539.

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