NCT02994173 (DoseRespKeta) is a Phase 4 clinical trial of Oxycodone in Pain, Postoperative, sponsored by Turku University Hospital.

Who is sponsoring NCT02994173?

NCT02994173 is sponsored by Turku University Hospital.

What drugs are being tested in NCT02994173?

Interventions in NCT02994173: Oxycodone, S-Ketamine 0.25, S-Ketamine 0.5, S-Ketamine 0.75.

What condition does NCT02994173 study?

NCT02994173 studies Pain, Postoperative.

Is NCT02994173 still recruiting?

NCT02994173 is currently completed. Last updated 11 December 2019.

Last reviewed 2019-12-11 · How we verify

NCT02994173: DoseRespKeta

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Dose-response of Ketamine in Patient Controlled Analgesia in Orthopaedic Surgery Patients

Completed Phase 4 Last updated 11 December 2019

What this trial tests

Phase 4 trial testing Oxycodone in Pain, Postoperative in 100 participants. Completed in 5 December 2019.

Timeline

1 February 2017

Primary endpoint
3 November 2019

5 December 2019

Quick facts

Lead sponsor	Turku University Hospital
Phase	Phase 4
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	100
Start date	1 February 2017
Primary completion	3 November 2019
Estimated completion	5 December 2019
Sites	1 location across Finland

Drugs / interventions tested

Oxycodone (oxycodone) — full drug profile →
S-Ketamine 0.25 — full drug profile →
S-Ketamine 0.5 — full drug profile →
S-Ketamine 0.75 — full drug profile →

Conditions studied

Pain, Postoperative — all drugs for Pain, Postoperative →

Sponsor

Turku University Hospital

Who can join

Adults 20 to 75, any sex, with Pain, Postoperative. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

To study the multimodal protocol combining adjunct ketamine with oxycodone in intravenous patient-controlled analgesia bolus dosing and effects in patients scheduled for posterolateral lumbar spine fusion with bilateral transpedicular screw instrumentation

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

S-ketamine in patient-controlled analgesia reduces opioid consumption in a dose-dependent manner after major lumbar fusion surgery: A randomized, double-blind, placebo-controlled clinical trial.
Brinck ECV, Virtanen T, Mäkelä S, Soini V, et al · · 2021 · cited 33× · PMID 34097713 · DOI 10.1371/journal.pone.0252626

Verify or expand the search:

Other trials of Oxycodone

Trials testing the same drug.

NCT07153003 — Efficacy And Safety Of Tramadol And Oxycodone Versus Oxycodone Monotherapy For Pain Control After Primary Total Knee And · Phase 4 · enrolling by invitation
NCT06757140 — Opioid Drug Interaction Study · Phase 1, PHASE2 · recruiting
NCT05965492 — Multimodal Pain Package vs. Regular Formulation for Pain Management in Ambulatory Spinal Surgery · Phase 3 · withdrawn
NCT06517069 — Effect of TEAS Combined With Oxycodone on Postoperative Visceral Pain in Gynecologic Laparoscopic Patients · NA · recruiting
NCT06340932 — Impact of Opioid Avoidance Protocol for ACL Reconstruction · completed

Other recruiting trials for Pain, Postoperative

Currently open trials in the same condition.

NCT07512141 — Single Versus Double Drains in the Axillary and Pectoral Regions After Modified Radical Mastectomy · NA · recruiting
NCT07354581 — Erector Spinae Plane Block vs Quadro-Iliac Plane Block After Lumbar Instrumentation Surgery · NA · recruiting
NCT07239817 — PENG Block + LIA For Endoprosthesis Surgery With Anterior Approach · NA · recruiting
NCT06740214 — Analgesic Efficacy of Different Liposomal Bupivacaine Doses in the Adductor Canal Block for Total Knee Arthroplasty · Phase 3 · recruiting
NCT07057557 — Aloe Vera vs Paraffin Tulle Dressings for Pain Management in Split Thickness Skin Graft Donor Sites · NA · recruiting

Other Turku University Hospital trials

Trials by the same sponsor.

NCT07488494 — Effective Implementation of the Physical Activity and Motor Skills Intervention for 3-6-year-old Children With Cancer (E · NA · not yet recruiting
NCT07316868 — Neuroprotective Effect of Mild Hypothermia Versus Normothermia During Cardiopulmonary Bypass of Coronary Artery Surgery · NA · not yet recruiting
NCT07306000 — Pilot Study: Effects of CCP Intervention on NICU Environment and Preterm Infants Development · NA · recruiting
NCT07272824 — Usability Study of Gestational and Postpartum Weight Management Program · recruiting
NCT07310472 — Administration of the Nasal Influenza Vaccine to Children in Daycare or at a Healthcare Facility · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02994173 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Turku University Hospital
Last refreshed: 11 December 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02994173.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing