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NCT02985918
High-Intensity vs Low-Intensity NPPV in Patients With an AECOPD: The HAPPEN Trial
NA trial testing High-intensity NPPV in Acute Exacerbation of Chronic Obstructive Pulmonary Disease in 300 participants. Terminated before completion.
31 January 2022
Quick facts
| Lead sponsor | Beijing Chao Yang Hospital |
|---|---|
| Phase | NA |
| Status | Terminated |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 300 |
| Start date | 3 January 2019 |
| Primary completion | 31 January 2022 |
| Estimated completion | 22 April 2022 |
| Sites | 31 locations across China |
Drugs / interventions tested
- High-intensity NPPV
- Low-intensity NPPV
Conditions studied
- Acute Exacerbation of Chronic Obstructive Pulmonary Disease — all drugs for Acute Exacerbation of Chronic Obstructive Pulmonary Disease →
Sponsor
Beijing Chao Yang Hospital
Who can join
18 and older, any sex, with Acute Exacerbation of Chronic Obstructive Pulmonary Disease. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
To determine whether high-intensity NPPV, compared with low-intensity NPPV, could reduce the need for endotracheal intubation during hospitalization in patients with an AECOPD and hypercapnia.
Publications & conference data
2 peer-reviewed publications reference this trial (live from Europe PMC):
-
Effect of High-Intensity vs Low-Intensity Noninvasive Positive Pressure Ventilation on the Need for Endotracheal Intubation in Patients With an Acute Exacerbation of Chronic Obstructive Pulmonary Disease: The HAPPEN Randomized Clinical Trial.
Luo Z, Li Y, Li W, Li Y, et al · · 2024 · cited 15× · PMID 39283649 · DOI 10.1001/jama.2024.15815 -
High-intensity versus low-intensity noninvasive positive pressure ventilation in patients with acute exacerbation of chronic obstructive pulmonary disease (HAPPEN): study protocol for a multicenter randomized controlled trial.
Luo Z, Wu C, Li Q, Zhu J, et al · · 2018 · cited 3× · PMID 30463622 · DOI 10.1186/s13063-018-2991-y
Verify or expand the search:
- PubMed search for NCT02985918
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of High-intensity NPPV
Trials testing the same drug.
- NCT04044625 — Effects of High-intensity Noninvasive Positive Pressure Ventilation in AECOPD · NA · completed
Other Beijing Chao Yang Hospital trials
Trials by the same sponsor.
- NCT07520305 — Efficacy Heterogeneity of Lactobacillus Paracasei LC19 on Type 2 Diabetes · NA · not yet recruiting
- NCT07490925 — Transpulmonary Pressure-guided Mechanical Ventilation Strategy in Right Ventricular Protection in Patients With ARDS · NA · not yet recruiting
- NCT07382986 — IMPACT COPD Cohort (China) · recruiting
- NCT07323134 — The Effect of Semaglutide on the Intestinal Flora in Obesity · not yet recruiting
- NCT07049692 — Hyperbaric Oxygen After Stroke Thrombectomy: A Multicenter Randomized Trial on Safety and Efficacy · NA · not yet recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02985918 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Beijing Chao Yang Hospital
- Last refreshed: 7 February 2024
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02985918.
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