NCT02979886 is a NA clinical trial of GnRH-a in Infertility, Female, sponsored by Miao benyu.

Who is sponsoring NCT02979886?

NCT02979886 is sponsored by Miao benyu.

What drugs are being tested in NCT02979886?

Interventions in NCT02979886: GnRH-a, Human Menopausal Gonadotropins.

What condition does NCT02979886 study?

NCT02979886 studies Infertility, Female.

Is NCT02979886 still recruiting?

NCT02979886 is currently status unknown. Last updated 1 December 2016.

Last reviewed 2016-12-01 · How we verify

NCT02979886

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Effects of Single Nucleotide Polymorphism of GnRH Receptor Genes on Clinical Response to Pituitary Down Regulation in IVF Patients

Status unknown NA Last updated 1 December 2016

What this trial tests

NA trial testing GnRH-a in Infertility, Female in 1,500 participants. Status unknown.

Timeline

1 January 2017

Primary endpoint
1 June 2019

1 December 2019

Quick facts

Lead sponsor	Miao benyu
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	screening
Enrollment	1,500
Start date	1 January 2017
Primary completion	1 June 2019
Estimated completion	1 December 2019

Drugs / interventions tested

GnRH-a
Human Menopausal Gonadotropins — full drug profile →

Conditions studied

Infertility, Female — all drugs for Infertility, Female →

Sponsor

Miao benyu — full company profile →

Who can join

Adults 20 to 40, female only, with Infertility, Female. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

the evidence of the correlation between single nucleotide polymorphism (SNP) of GnRH receptor genes in infertile female patients and the extent of pituitary down-regulation by short-acting GnRH-a long protocol
Time frame: two years

Sponsor's own description

Gonadotropin-releasing hormone analogue (GnRH-a) "long protocol" is a protocol for pituitary down-regulation in IVF. However, it is common in clinic that some patients are hypersensitive to pituitary down-regulation and have pituitary oversuppression, resulting in prolonged ovarian stimulation and increased consumption of exogenous gonadotropin(Gn). On the other hand, some patients may have insufficient pituitary down-regulation, which can affect the synchronization of ovarian follicles and consequently reduce the number of oocytes retrievable and lower the pregnancy rate. The differences in responses to GnRH-a among patients may be associated with the SNP of their GnRH receptor genes. It has been reported that mutations in GnRH receptor genes could change their binding affinity to the ligands, thus affecting the outcome of pituitary down-regulation. So far 20 non-synonymous mutations on the GnRH receptor genes have been reported, which can affect the function of GnRH receptor and are highly associated with disorders such as endometriosis and sexual precocity. However, the correlation between the SNP of GnRH receptor genes and the outcome of pituitary down-regulation in IVF has not been reported. The purpose of this study is to analyze the correlation between single nucleotide polymorphism (SNP) of GnRH receptor genes in infertile female patients and the extent of pituitary down-regulation by short-acting GnRH-a long protocol, with the goal to achieve individual down-regulation protocols based on the patients' SNP haplotypes of GnRH receptor genes and to improve the success rate of assisted reproductive technology.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

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NCT07175571 — SISTER: Sibling Oocyte Insemination With Frozen Sperm From Third Party Donors: Evaluation of Reproductive Techniques · NA · recruiting
NCT06193135 — Usefulness of Corifollitropin α as Alternative to Conventional Daily rFSH Protocols in Oocyte Donors Undergoing Pituitar · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02979886 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Miao benyu
Last refreshed: 1 December 2016

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02979886.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing