NCT02977819: Age-Well

Study in Cognitively Intact Seniors Aiming to Assess the Effects of Meditation Training

Completed NA Last updated 10 February 2025

What this trial tests

NA trial testing Meditation practice in Cognitive Aging in 137 participants. Completed in 9 December 2023.

Timeline

24 November 2016

Primary endpoint
31 December 2019

9 December 2023

Quick facts

Lead sponsor	Institut National de la Santé Et de la Recherche Médicale, France
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	prevention
Enrollment	137
Start date	24 November 2016
Primary completion	31 December 2019
Estimated completion	9 December 2023
Sites	1 location across France

Drugs / interventions tested

• Meditation practice
• Learning English as a foreign language

Conditions studied

• Cognitive Aging — all drugs for Cognitive Aging →

Sponsor

Institut National de la Santé Et de la Recherche Médicale, France — full company profile →

Who can join

65 and older, any sex, with Cognitive Aging. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

As the number of older people in Europe grows, increasing healthy life years is a priority. As people live longer, ensuring good mental as well as physical health into later years is becoming ever more important. Cognitive decline, dementia (e.g. Alzheimer's Disease, AD), sleep disturbances and depression, all related to psychological distress and anxiety, are significant drivers of reduced quality of life in older adults. This project builds on evidence that meditation practice have the potential to downregulate these adverse factors and positively impact mental and neurological conditions including AD.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. Association of Sleep-Disordered Breathing With Alzheimer Disease Biomarkers in Community-Dwelling Older Adults: A Secondary Analysis of a Randomized Clinical Trial.
   André C, Rehel S, Kuhn E, Landeau B, et al · · 2020 · cited 96× · PMID 32202593 · DOI 10.1001/jamaneurol.2020.0311
2. The Age-Well randomized controlled trial of the Medit-Ageing European project: Effect of meditation or foreign language training on brain and mental health in older adults.
   Poisnel G, Arenaza-Urquijo E, Collette F, Klimecki OM, et al · · 2018 · cited 67× · PMID 30581977 · DOI 10.1016/j.trci.2018.10.011
3. Depressive symptoms in cognitively unimpaired older adults are associated with lower structural and functional integrity in a frontolimbic network.
   Touron E, Moulinet I, Kuhn E, Sherif S, et al · · 2022 · cited 46× · PMID 36258017 · DOI 10.1038/s41380-022-01772-8
4. Effect of an 18-Month Meditation Training on Regional Brain Volume and Perfusion in Older Adults: The Age-Well Randomized Clinical Trial.
   Chételat G, Lutz A, Klimecki O, Frison E, et al · · 2022 · cited 32× · PMID 36215061 · DOI 10.1001/jamaneurol.2022.3185
5. Age-related changes in fast spindle clustering during non-rapid eye movement sleep and their relevance for memory consolidation.
   Champetier P, André C, Weber FD, Rehel S, et al · · 2023 · cited 25× · PMID 36433753 · DOI 10.1093/sleep/zsac282
6. Role of Cardiovascular Risk Factors on the Association Between Physical Activity and Brain Integrity Markers in Older Adults.
   Felisatti F, Gonneaud J, Palix C, Garnier-Crussard A, et al · · 2022 · cited 23× · PMID 35418459 · DOI 10.1212/wnl.0000000000200270
7. Dynamic functional connectivity patterns associated with dementia risk.
   Dautricourt S, Gonneaud J, Landeau B, Calhoun VD, et al · · 2022 · cited 22× · PMID 35606867 · DOI 10.1186/s13195-022-01006-7
8. Association of Sleep-Disordered Breathing and Medial Temporal Lobe Atrophy in Cognitively Unimpaired Amyloid-Positive Older Adults.
   André C, Kuhn E, Rehel S, Ourry V, et al · · 2023 · cited 20× · PMID 37258299 · DOI 10.1212/wnl.0000000000207421