NCT02973139 is a NA clinical trial of Medical Thoracoscopy in Pleural Infection, sponsored by Beth Israel Deaconess Medical Center.

Who is sponsoring NCT02973139?

NCT02973139 is sponsored by Beth Israel Deaconess Medical Center.

What drugs are being tested in NCT02973139?

Interventions in NCT02973139: Medical Thoracoscopy, Fibrinolytic Group.

What condition does NCT02973139 study?

NCT02973139 studies Pleural Infection, Pleural Diseases.

Is NCT02973139 still recruiting?

NCT02973139 is currently completed. Last updated 26 December 2019.

Last reviewed 2019-12-26 · How we verify

NCT02973139

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Fibrinolysis Compared to Thoracoscopy for Pleural Infection

Completed NA Last updated 26 December 2019

What this trial tests

NA trial testing Medical Thoracoscopy in Pleural Infection in 32 participants. Completed in 1 November 2019.

Timeline

14 July 2017

Primary endpoint
1 November 2019

1 November 2019

Quick facts

Lead sponsor	Beth Israel Deaconess Medical Center
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	32
Start date	14 July 2017
Primary completion	1 November 2019
Estimated completion	1 November 2019
Sites	1 location across United States

Drugs / interventions tested

Medical Thoracoscopy
Fibrinolytic Group

Conditions studied

Pleural Infection — all drugs for Pleural Infection →
Pleural Diseases — all drugs for Pleural Diseases →

Sponsor

Beth Israel Deaconess Medical Center

Who can join

18 and older, any sex, with Pleural Infection or Pleural Diseases. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The purpose of this prospective randomized clinical trial is to compare two currently accepted standard-of-care treatment strategies: Medical thoracoscopy as compared to instillation of intrapleural tissue Plasminogen Activator (TPA) and human recombinant Deoxyribonuclease (DNase) for the management of empyema or complex parapneumonic effusion (CPPE) in adults.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

Intra-pleural fibrinolytic therapy versus placebo, or a different fibrinolytic agent, in the treatment of adult parapneumonic effusions and empyema.
Altmann ES, Crossingham I, Wilson S, Davies HR. · · 2019 · cited 52× · PMID 31684683 · DOI 10.1002/14651858.cd002312.pub4
Intrapleural Fibrinolytic Therapy versus Early Medical Thoracoscopy for Treatment of Pleural Infection. Randomized Controlled Clinical Trial.
Kheir F, Thakore S, Mehta H, Jantz M, et al · · 2020 · cited 39× · PMID 32421353 · DOI 10.1513/annalsats.202001-076oc
Medical thoracoscopy and its evolving role in the diagnosis and treatment of pleural disease.
Murthy V, Bessich JL. · · 2017 · cited 32× · PMID 29214061 · DOI 10.21037/jtd.2017.06.37
Pleuroscopy or video-assisted thoracoscopic surgery for exudative pleural effusion: a comparative overview.
Ali MS, Light RW, Maldonado F. · · 2019 · cited 25× · PMID 31463153 · DOI 10.21037/jtd.2019.03.86

Verify or expand the search:

Other trials of Medical Thoracoscopy

Trials testing the same drug.

NCT03468933 — Fibrinolysis Compared to Thoracoscopy for Pleural Infection · Phase 4 · completed

Other recruiting trials for Pleural Infection

Currently open trials in the same condition.

NCT05766124 — Trial of Reduced Alteplase Dose for Parapneumonic Effusion (TRAPPE) · Phase 2, PHASE3 · recruiting
NCT06427538 — Chest Drain Regular Flushing in Complicated Parapneumonic Effusions and Empyemas · NA · recruiting
NCT07194915 — Pleural Fluid Neutrophil Extracellular Traps Exacerbate Disease Severity and Risk of One-year Mortality in Pleural Infec · active not recruiting

Other Beth Israel Deaconess Medical Center trials

Trials by the same sponsor.

NCT07352657 — Remote Alert Pathway To Optimize CaRe of Cardiac Implantable Electrical Devices: The RAPTOR-CIED Study (Main Phase) · NA · not yet recruiting
NCT07531602 — Effect of PEEP on Cardiac Function · NA · not yet recruiting
NCT07534683 — Primed to Thrive: Investigating the Combined Impact of Mindfulness Education and Meditation Practice on Psychological an · NA · not yet recruiting
NCT07277244 — Low-Intensity Mechanical Ventilation in the Operating Room: a Pilot Study · NA · enrolling by invitation
NCT06896474 — SDM POSSIBLE: A Breast Cancer Treatment Decision Aid for Women 70+ With Low-Risk Stage I Breast Cancers · NA · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02973139 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Beth Israel Deaconess Medical Center
Last refreshed: 26 December 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02973139.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing