Last reviewed · How we verify
NCT02968654: TRAIN
TRansfusion Strategies in Acute Brain INjured Patients
Completed
NA
Last updated 7 September 2023
What this trial tests
NA trial testing Restrictive Transfusion Strategy in Acute Brain Injury in 850 participants. Completed in 30 June 2023.
Timeline
13 September 2016
Primary endpoint
31 December 2022
31 December 2022
30 June 2023
Quick facts
| Lead sponsor | Erasme University Hospital |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 850 |
| Start date | 13 September 2016 |
| Primary completion | 31 December 2022 |
| Estimated completion | 30 June 2023 |
| Sites | 1 location across Belgium |
Drugs / interventions tested
- Restrictive Transfusion Strategy
- Liberal Transfusion Strategy
Conditions studied
- Acute Brain Injury — all drugs for Acute Brain Injury →
- Blood Transfusion — all drugs for Blood Transfusion →
Sponsor
Erasme University Hospital
Who can join
Adults 18 to 80, any sex, with Acute Brain Injury or Blood Transfusion. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
To compare a "liberal" and a "restrictive" strategy to administer blood transfusions in critically ill patients with a primary brain injury.
Publications & conference data
8 peer-reviewed publications reference this trial (live from Europe PMC):
-
Transfusion strategies in non-bleeding critically ill adults: a clinical practice guideline from the European Society of Intensive Care Medicine.
Vlaar AP, Oczkowski S, de Bruin S, Wijnberge M, et al · · 2020 · cited 160× · PMID 31912207 · DOI 10.1007/s00134-019-05884-8 -
Restrictive vs Liberal Transfusion Strategy in Patients With Acute Brain Injury: The TRAIN Randomized Clinical Trial.
Taccone FS, Rynkowski CB, Møller K, Lormans P, et al · · 2024 · cited 95× · PMID 39382241 · DOI 10.1001/jama.2024.20424 -
Transfusion practice in the non-bleeding critically ill: an international online survey-the TRACE survey.
de Bruin S, Scheeren TWL, Bakker J, van Bruggen R, et al · · 2019 · cited 50× · PMID 31511083 · DOI 10.1186/s13054-019-2591-6 -
Management and prevention of anemia (acute bleeding excluded) in adult critical care patients.
Lasocki S, Pène F, Ait-Oufella H, Aubron C, et al · · 2020 · cited 35× · PMID 32700082 · DOI 10.1186/s13613-020-00711-6 -
Protocolized Brain Oxygen Optimization in Subarachnoid Hemorrhage.
Rass V, Solari D, Ianosi B, Gaasch M, et al · · 2019 · cited 29× · PMID 31218640 · DOI 10.1007/s12028-019-00753-0 -
Transfusion practices in traumatic brain injury.
East JM, Viau-Lapointe J, McCredie VA. · · 2018 · cited 27× · PMID 29369066 · DOI 10.1097/aco.0000000000000566 -
Early management of isolated severe traumatic brain injury patients in a hospital without neurosurgical capabilities: a consensus and clinical recommendations of the World Society of Emergency Surgery (WSES).
Picetti E, Catena F, Abu-Zidan F, Ansaloni L, et al · · 2023 · cited 19× · PMID 36624517 · DOI 10.1186/s13017-022-00468-2 -
TRansfusion strategies in Acute brain INjured patients (TRAIN): a prospective multicenter randomized interventional trial protocol.
Taccone FS, Badenes R, Rynkowski CB, Bouzat P, et al · · 2023 · cited 18× · PMID 36611210 · DOI 10.1186/s13063-022-07061-7
Verify or expand the search:
- PubMed search for NCT02968654
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Restrictive Transfusion Strategy
Trials testing the same drug.
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- NCT02042898 — Transfusion Requirements in Cardiac Surgery III · NA · completed
Other recruiting trials for Acute Brain Injury
Currently open trials in the same condition.
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- NCT06542107 — Weaning From Mechanical Ventilation in Patients With Acute Brain Injury · recruiting
- NCT06469801 — ECMO ABI Detection With Hyperfine · NA · recruiting
- NCT06426615 — Connectivity and Neural Signatures of Consciousness in Unresponsive States · NA · recruiting
- NCT04080440 — Brain-injured Patients Extubation Readiness Study · NA · recruiting
Other Erasme University Hospital trials
Trials by the same sponsor.
- NCT07532733 — Respiratory and Haemodynamic Effects of Conscious Sedation With Dexmedetomidine for a TAVI Procedure · NA · not yet recruiting
- NCT07532681 — Effect of Early Versus Late Surgical Intercostal Block on Postoperative Pain Relief Following Video-Assisted Thoracic Su · NA · not yet recruiting
- NCT07457879 — Impact of the Reimbursement of Fibrinogen in Cardiac Surgery · not yet recruiting
- NCT07184593 — Nucleosome Monitoring Relevance for Outcome Prediction in Critically Ill Patients · not yet recruiting
- NCT07369232 — Cerebral Hemodynamic Effects of Oxygen and Antioxidants (CHEOXANT) · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
Data sources for this page
- Trial protocol + status: ClinicalTrials.gov NCT02968654 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Erasme University Hospital
- Last refreshed: 7 September 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02968654.
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