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NCT02967640
Does Subacromial Injection With Glutamate Receptor Antagonist, Ketamine, Attenuate Pain in Rotator Cuff Tendinopathy?
Phase 2, PHASE3 trial testing Ketalar in Rotator Cuff Tendinitis in 14 participants. Completed in 30 December 2024.
30 December 2024
Quick facts
| Lead sponsor | Helse Møre og Romsdal HF |
|---|---|
| Phase | Phase 2, PHASE3 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 14 |
| Start date | 30 May 2018 |
| Primary completion | 30 December 2024 |
| Estimated completion | 30 December 2024 |
| Sites | 1 location across Norway |
Drugs / interventions tested
Conditions studied
- Rotator Cuff Tendinitis — all drugs for Rotator Cuff Tendinitis →
- Chronic Pain — all drugs for Chronic Pain →
Sponsor
Helse Møre og Romsdal HF — full company profile →
Who can join
40 and older, any sex, with Rotator Cuff Tendinitis or Chronic Pain. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The hypothesis of the present study is that in patients with rotator cuff tendinopathy a specific pharmacological blocking of peripheral glutamate-receptor N-methyl-d-aspartate receptor type1 (NMDAR) glutamate receptors will result in pain alleviation. Activated NMDAR1 has been demonstrated to be crucial for pain regulation in various pain disorders, and in biopsies from patients with tendinopathy, NMDAR1 was found to be activated. To test this hypothesis a specific NMDA receptor antagonist, ketalar (ketamine), will be injected guided by ultrasound into the subacromial space in patients with rotator cuff tendinopathy, and subsequently the pain response will be assessed.
Publications & conference data
No peer-reviewed publications indexed yet for this trial. Completed trials usually publish results within 12-18 months.
Verify or expand the search:
- PubMed search for NCT02967640
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Related trials
Other trials of Ketalar
Trials testing the same drug.
- NCT06473896 — Effect of Ketalar or Dexmedetomidine on Increased Sensitivity to Pain Following Treatment With Remifentanil · NA · recruiting
- NCT07034911 — Ketamine vs Ephedrine on Post Spinal Hypotension in Caesarean Delivery · Phase 1 · completed
- NCT03375671 — Rapid Agitation Control With Ketamine in the Emergency Department · Phase 2 · completed
Other recruiting trials for Rotator Cuff Tendinitis
Currently open trials in the same condition.
- NCT06095050 — Embolization Treatment of Chronic Refractory Shoulder Tendinopathy · NA · recruiting
- NCT06702319 — Effects of Externally Focused Shoulder Stabilization Exercises on Individuals With Rotator Cuff Tendinopathy · NA · active not recruiting
- NCT06160427 — Connective Tissue Matrix for Rotator Cuff Tendinopathy · Phase 4 · active not recruiting
- NCT04923477 — Therapeutic Exercise for Rotator Cuff Tendinopathy / Subacromial Pain Syndrome - Outcomes and Mechanisms · NA · recruiting
- NCT04094298 — Use of Extended Release Triamcinolone in the Treatment of Rotator Cuff Disease · Phase 3 · active not recruiting
Other Helse Møre og Romsdal HF trials
Trials by the same sponsor.
- NCT07381790 — Modern Technologies in Lower Respiratory Tract Infections in Children · recruiting
- NCT07021274 — DBT Skill Training for Autistic Adults With Difficulties in Emotion Regulation. · NA · not yet recruiting
- NCT06458374 — ATTR Cardiac Amyloidosis in a Selected Population · recruiting
- NCT06507046 — The personalKNEE Trial · NA · recruiting
- NCT06499038 — The Ace Avanteon Study - A Randomized Controled Trial · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02967640 (US National Library of Medicine, public domain)
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Helse Møre og Romsdal HF
- Last refreshed: 22 August 2025
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02967640.
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