NCT02966158: CAT vs MICE

A Randomized Controlled Trial in Women With Coronary Artery Disease Investigating the Effects of Aerobic Interval Training Versus Moderate Intensity Continuous Exercise

Completed NA Last updated 2 December 2019

What this trial tests

NA trial testing AIT Group in Coronary Artery Disease in 31 participants. Completed in 22 October 2019.

Timeline

1 March 2017

Primary endpoint
31 August 2019

22 October 2019

Quick facts

Lead sponsor	University Health Network, Toronto
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	prevention
Enrollment	31
Start date	1 March 2017
Primary completion	31 August 2019
Estimated completion	22 October 2019
Sites	1 location across Canada

Drugs / interventions tested

• AIT Group

Conditions studied

• Coronary Artery Disease — all drugs for Coronary Artery Disease →

Sponsor

University Health Network, Toronto

Who can join

Eligibility, female only, with Coronary Artery Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Heart disease is the number one killer amongst chronic diseases around the world, and it is responsible for taking the lives of an estimated 17.5 million people each year. Exercise-based cardiac rehabilitation (CR) programs, which help heart patients improve their current health, prevent future heart problems, and improve their quality of life, are an effective strategy for lowering the risk of heart-related deaths in heart patients. CR programs currently have their patients perform moderate intensity, continuous exercise (MICE), which traditionally takes the form of walking, jogging, or cycling at a comfortable pace for 30-60 minutes. Recently, aerobic interval training (AIT), which involves performing short bouts of exercise, typically ranging from 15 seconds to four minutes at near maximal effort, followed by periods of recovery or rest, has emerged as a more effective strategy than MICE for lowering the risk of heart-related deaths in heart patients. Although these initial findings appear to hold much promise for improving CR programs in the future, it is important to recognize that women have been underrepresented or not included in these studies to date. Therefore, the goal of this study is to determine the effects of AIT versus MICE on the risk of heart-related death, blood vessel health, and brain health in women who have heart disease, and who have been referred to a six-month, outpatient CR program.

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Randomised controlled trial in women with coronary artery disease investigating the effects of aerobic interval training versus moderate intensity continuous exercise in cardiac rehabilitation: CAT versus MICE study.
   Lee LS, Tsai MC, Brooks D, Oh PI. · · 2019 · cited 21× · PMID 31749981 · DOI 10.1136/bmjsem-2019-000589