The Effect of Dopamine on Pulmonary Diffusion and Capillary Blood Volume During Exercise

NCT02965963 NA COMPLETED

The purpose of this study is to examine the effect of dopamine infusion and dopamine-2 receptor blockade on pulmonary capillary blood volume, diffusion, and the hemodynamic variables of pulmonary artery pressure, cardiac output, and pulmonary vascular resistance during exercise. Secondarily, this study will examine the effect of dopamine infusion and dopamine-2 receptor blockade on exercise tolerance.

Details

Lead sponsor	University of Alberta
Phase	NA
Status	COMPLETED
Enrolment	49
Start date	2016-12
Completion	2025-06

Conditions

• Health

Interventions

• Dopamine
• Metoclopramide
• Placebos
• Rest
• Exercise - 60%
• Exercise - 85%

Primary outcomes

• Change in Pulmonary Capillary Blood Volume — Dopamine (Day 1), Metoclopramide (Day 2), Placebos (Day 3) *order randomized
  Roughton and Forster's Three FIO2 DLCO Method at Rest, 60% of Vo2max, and 85% of Vo2max
• Diffusing Capacity for Carbon Monoxide — Dopamine (Day 1), Metoclopramide (Day 2), Placebos (Day 3) *order randomized
  Roughton and Forster's Three FIO2 DLCO Method at Rest, 60% of Vo2max, and 85% of Vo2max
• Pulmonary Artery Systolic Pressure — Dopamine (Day 1), Metoclopramide (Day 2), Placebos (Day 3) *order randomized
  Non-invasive estimation using Doppler echocardiography at Rest \& 60% of Vo2max
• Cardiac Output — Dopamine (Day 1), Metoclopramide (Day 2), Placebos (Day 3) *order randomized
  Non-invasive estimation using trans-thoracic impedance cardiography at rest, 60% of Vo2max, and 85% of Vo2max
• Pulmonary Vascular Resistance — Dopamine (Day 1), Metoclopramide (Day 2), Placebos (Day 3) *order randomized
  Calculation

Countries

Canada