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NCT02962921
Acute Insulin Effects on Cardiac Function in Patients With Diabetes Mellitus
Phase 4 trial testing Insulin LISPRO intravenous loading in Diabetes Mellitus in 6 participants. Completed in 1 November 2004.
1 May 2003
Quick facts
| Lead sponsor | Rambam Health Care Campus |
|---|---|
| Phase | Phase 4 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 6 |
| Start date | 1 February 2003 |
| Primary completion | 1 May 2003 |
| Estimated completion | 1 November 2004 |
| Sites | 1 location across Israel |
Drugs / interventions tested
- Insulin LISPRO intravenous loading — full drug profile →
Conditions studied
- Diabetes Mellitus — all drugs for Diabetes Mellitus →
- Ventricular Dysfunction — all drugs for Ventricular Dysfunction →
Sponsor
Rambam Health Care Campus — full company profile →
Who can join
Adults 30 to 65, male only, with Diabetes Mellitus or Ventricular Dysfunction. Patients with the condition only — healthy volunteers not accepted.
What's being measured
Primary outcomes are the specific endpoints the trial is designed to prove or disprove.
-
Left ventricle ejection fraction (%)
Time frame: 1 year
Sponsor's own description
Our investigation studies the role of acute insulin administration on the diabetic heart, its corresponding effective blood-insulin level and the time-course applicability of insulin in a routine clinical setting. A case series of six male (48.1 ± 4.9 y/o) patients with controlled diabetes (HbA1c of 6.6 ± 0.3%, disease duration of 14.4 ± 6.7 yr). Each subject was evaluated for glucose homeostatic, hemodynamic and echocardiographic systolic and diastolic parameters at baseline and following two successive insulin-load steps of a euglycemic hyperinsulinemic clamp study, each 2 h in duration. Results are presented as a mean ± SEM and analysed using the student's t-test.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Acute Effects of Insulin on Cardiac Function in Patients with Diabetes Mellitus: Clinical Applicability and Feasibility.
Daoud Naccache D, Yalonetsky S, Bar-Yoseph R. · · 2020 · cited 1× · PMID 32308680 · DOI 10.1155/2020/8134548
Verify or expand the search:
- PubMed search for NCT02962921
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Other Rambam Health Care Campus trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02962921 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Rambam Health Care Campus
- Last refreshed: 9 November 2016
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02962921.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing