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Treatment of Knee Arthrosis: Platelet-derived Growth Factors vs. Hyaluronic Acid. A Phase II-III Randomized Controlled Trial
Primary aim of this trial was to assess efficacy three intraarticular injections of platelet lysate when compared to hyaluronic acid. Additional objectives were to compare the treatment groups in terms of a number of functional scales and of number of adverse events.
Details
| Lead sponsor | Fondazione IRCCS Policlinico San Matteo di Pavia |
|---|---|
| Phase | Phase 2 |
| Status | COMPLETED |
| Enrolment | 58 |
| Start date | 2010-08 |
| Completion | 2014-07 |
Conditions
- Knee Osteoarthrosis
Interventions
- intraarticular injections of platelet lysate
- hyaluronic acid
Primary outcomes
- Efficacy (as determined by improvement at MRI 6 months after the first injection) of intraarticular injections of platelet lysate — Six months after the last infiltration
Each knee was improvement, from baseline, by at least one degree the maximum MRI score (Shahriaree Classification System - modified) at 6 month