A Comparative Study for the Effects of Nifedipine GITS and Amlodipine Besylate on Recovery of Blood Pressure Rhythm and Arterial Stiffness in the Young and Middle-aged Subjects With Non-dipper Hypertension (NARRAS)

NCT02940548 Phase 4 TERMINATED

This trial evaluates the effects of Nifedipine GITS and Amlodipine besylate on blood pressure rhythm restoration and arterial stiffness in young and middle-aged non-dipper hypertensives. Half of participants will receive Nifedipine GITS, half of half will take medicine in the morning or at night. While the other half participants will take amlodipine besylate, whom will also be assigned taking medicine in the morning or at night. Ambulatory blood pressure monitoring and arterial stiffness examination will be performed before and after pharmaceutical intervention.

Details

Lead sponsor	Jing Liu
Phase	Phase 4
Status	TERMINATED
Enrolment	99
Start date	2016-12
Completion	2020-12

Conditions

• Hypertension

Interventions

• Nifedipine GITS
• Amlodipine besylate

Primary outcomes

• Nighttime systolic blood pressure reduction — 8 weeks
  Compare the effects of two active drugs on nighttime systolic blood pressure reduction

Countries

China