NCT02936505 (ScanCLAD) is a NA clinical trial of Cyclosporine in Lung Transplantation, sponsored by Vastra Gotaland Region.

Who is sponsoring NCT02936505?

NCT02936505 is sponsored by Vastra Gotaland Region.

What drugs are being tested in NCT02936505?

Interventions in NCT02936505: Cyclosporine, Mycophenolate mofetil (MMF), Rabbit Anti thymocyte globulin, Corticosteroids, Tacrolimus.

What condition does NCT02936505 study?

NCT02936505 studies Lung Transplantation, Allografts.

Is NCT02936505 still recruiting?

NCT02936505 is currently active, enrolled. Last updated 26 April 2023.

Last reviewed 2023-04-26 · How we verify

NCT02936505: ScanCLAD

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Clinical Study Evaluating Two Treatment Protocols for Immunosuppressive Drugs. Looking at 3-year Incidence of CLAD.

Active, enrolled NA Last updated 26 April 2023

What this trial tests

NA trial testing Cyclosporine in Lung Transplantation in 249 participants. Participants enrolled and being followed up; not accepting new ones.

Timeline

12 October 2016

Primary endpoint
30 October 2025

30 October 2026

Quick facts

Lead sponsor	Vastra Gotaland Region
Phase	NA
Status	Active, enrolled
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	249
Start date	12 October 2016
Primary completion	30 October 2025
Estimated completion	30 October 2026
Sites	5 locations across Denmark, Finland, Sweden, Norway

Drugs / interventions tested

Cyclosporine (cyclosporine) — full drug profile →
Mycophenolate mofetil (MMF) — full drug profile →
Rabbit Anti thymocyte globulin
Corticosteroids (corticosteroids) — full drug profile →
Tacrolimus (TACROLIMUS) — full drug profile →

Conditions studied

Lung Transplantation — all drugs for Lung Transplantation →
Allografts — all drugs for Allografts →

Sponsor

Vastra Gotaland Region — full company profile →

Who can join

Adults 18 to 70, any sex, with Lung Transplantation or Allografts. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

A controlled randomized, open-label, multi-centre study evaluating if an immunosuppressive protocol, based on ATG-induction, once daily tacrolimus-dose (Advagraf®), mycophenolate mofetil and corticosteroid reduces the incidence of chronic lung allograft dysfunction (CLAD) after lung transplantation, in comparison with a standard cyclosporin-based protocol.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

Matrisome Properties of Scaffolds Direct Fibroblasts in Idiopathic Pulmonary Fibrosis.
Elowsson Rendin L, Löfdahl A, Åhrman E, Müller C, et al · · 2019 · cited 48× · PMID 31426504 · DOI 10.3390/ijms20164013
International consensus recommendations for anesthetic and intensive care management of lung transplantation. An EACTAIC, SCA, ISHLT, ESOT, ESTS, and AST approved document.
Marczin N, de Waal EEC, Hopkins PMA, Mulligan MS, et al · · 2021 · cited 42× · PMID 34732281 · DOI 10.1016/j.healun.2021.07.012
Effect of once-per-day tacrolimus versus twice-per-day ciclosporin on 3-year incidence of chronic lung allograft dysfunction after lung transplantation in Scandinavia (ScanCLAD): a multicentre randomised controlled trial.
Dellgren G, Lund TK, Raivio P, Leuckfeld I, et al · · 2024 · cited 27× · PMID 37703908 · DOI 10.1016/s2213-2600(23)00293-x
Design and Rationale of a Scandinavian Multicenter Randomized Study Evaluating if Once-Daily Tacrolimus Versus Twice-Daily Cyclosporine Reduces the 3-year Incidence of Chronic Lung Allograft Dysfunction After Lung Transplantation (ScanCLAD Study).
Dellgren G, Lund TK, Raivio P, Leuckfeld I, et al · · 2020 · cited 6× · PMID 31993943 · DOI 10.1007/s12325-020-01224-1
Heart transplantation in patients bridged with mechanical circulatory support: outcome comparison with matched controls.
Bartfay SE, Bobbio E, Esmaily S, Bergh N, et al · · 2023 · cited 5× · PMID 37343937 · DOI 10.1002/ehf2.14439
Extended use of extra corporeal membrane oxygenation as bridge to lung transplantation in two patients.
Skansebo E, Broomé M, Magnusson J, Riise GC, et al · · 2020 · cited 3× · PMID 31931854 · DOI 10.1186/s13019-020-1046-0
Design and Rationale of Cytokine Filtration in Lung Transplantation (GLUSorb): Protocol for a Multicenter Clinical Randomized Controlled Trial.
Lindstedt S, Silverborn M, Lannemyr L, Pierre L, et al · · 2023 · cited 2× · PMID 37855706 · DOI 10.2196/52553
Does donor age older or younger than 70 years influence lung transplantation outcomes?
Ögren E, Magnusson J, Tholén M, Hansson EC, et al · · 2026 · PMID 41960131 · DOI 10.1016/j.xjon.2025.101555

Verify or expand the search:

Other trials of Cyclosporine

Trials testing the same drug.

NCT07566377 — Cord Blood Transplantation in Children and Young Adults With Blood Cancer · Phase 2 · recruiting
NCT07352566 — Utilization of a Microdevice for Psoriasis and Atopic Dermatitis · Phase 4 · not yet recruiting
NCT06752694 — Ruxolitinib Based GVHD Prophylaxis Regimen Before, During, and After Hematopoietic Cell Transplantation in Older Adult P · Phase 2 · recruiting
NCT07196449 — Drug-Drug Interaction of Rifampicin and Cyclosporine on Methotrexate Pharmacokinetics in Healthy Subjects · Phase 1 · active not recruiting
NCT06892756 — Effect of Cyclosporine Drug Interaction on the Absorption, Metabolism and Elimination of CHF6001 in Healthy Volunteers. · Phase 1 · completed

Other recruiting trials for Lung Transplantation

Currently open trials in the same condition.

NCT07479511 — Adaptation of Lung Transplant Recipients at Extreme Altitude · active not recruiting
NCT06853223 — This Study is Assessing the Safety and Efficacy of Immune Inhibition as a Treatment to Prevent Primary Graft Dysfunction · Phase 2 · recruiting
NCT06868823 — Prospective Observational Pilot Study of LMWH Versus UFH as ECMO Anticoagulation in Lung Transplantation · recruiting
NCT07316829 — TRAnscriptional Profile of Peripheral Blood Cells in Patient With Chronic Kidney and Lung Rejection: Correlation With Re · active not recruiting
NCT06327945 — Transplanting Lungs From Uncontrolled Donation After Circulatory Death · NA · recruiting

Other Vastra Gotaland Region trials

Trials by the same sponsor.

NCT07430865 — The RECOVER Study - Postpartum Recovery of Pelvic Floor Structures and the Impact of Early Rehabilitation · NA · recruiting
NCT07472335 — Home-based Acute Care for Older Persons Initiated by the Emergency Medical and Ambulance Services - a Retrospective Obse · not yet recruiting
NCT07246577 — The VGR GCA Cohort: Ultrasound, Biopsy and Biomarkers - Novel Methods for Diagnosis, Monitoring and Prognosis in Giant C · recruiting
NCT07449338 — Prospective Cohort Study of Response and Tolerability of Accelerated Intermittent Theta-burst Stimulation (1W-AiTBS) · not yet recruiting
NCT07334340 — Modified vs Standard CDED: Evaluation of a Nordic Adaptation of Nutritional Therapy in Paediatric Crohn's Disease · NA · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02936505 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Vastra Gotaland Region
Last refreshed: 26 April 2023

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02936505.

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