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NCT02916524: PROCoM
Predicting Rehabilitation Outcomes in Bilingual Aphasia Using Computational Modeling
NA trial testing Semantic Feature Analysis (SFA) in Aphasia in 48 participants. Status unknown.
31 July 2021
Quick facts
| Lead sponsor | Boston University Charles River Campus |
|---|---|
| Phase | NA |
| Status | Status unknown |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | double |
| Primary purpose | treatment |
| Enrollment | 48 |
| Start date | 20 April 2018 |
| Primary completion | 31 July 2021 |
| Estimated completion | 31 July 2023 |
| Sites | 3 locations across United States |
Drugs / interventions tested
- Semantic Feature Analysis (SFA)
Conditions studied
- Aphasia — all drugs for Aphasia →
Sponsor
Boston University Charles River Campus
Who can join
Adults 18 to 85, any sex, with Aphasia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of this investigation is to implement a computational model that can predict and optimize training and cross-language generalization patterns for bilingual persons with aphasia (BPA). The proposed work will determine the best possible treatment program for each individual patient even before they are rehabilitated. In addition, the computational model allows specification of variables such as age of acquisition, language exposure/proficiency, impairment and their systematic influence on a range of language rehabilitation outcomes.
Publications & conference data
7 peer-reviewed publications reference this trial (live from Europe PMC):
-
Telerehabilitation for Word Retrieval Deficits in Bilinguals With Aphasia: Effectiveness and Reliability as Compared to In-person Language Therapy.
Peñaloza C, Scimeca M, Gaona A, Carpenter E, et al · · 2021 · cited 18× · PMID 34093382 · DOI 10.3389/fneur.2021.589330 -
Predicting treatment outcomes for bilinguals with aphasia using computational modeling: Study protocol for the PROCoM randomised controlled trial.
Peñaloza C, Dekhtyar M, Scimeca M, Carpenter E, et al · · 2020 · cited 13× · PMID 33208330 · DOI 10.1136/bmjopen-2020-040495 -
Clinical perspectives and strategies for confronting disparities in social determinants of health for Hispanic bilinguals with aphasia.
Scimeca M, Abdollahi F, Peñaloza C, Kiran S. · · 2022 · cited 11× · PMID 35688011 · DOI 10.1016/j.jcomdis.2022.106231 -
Multilevel factors predict treatment response following semantic feature-based intervention in bilingual aphasia.
Scimeca M, Peñaloza C, Kiran S. · · 2024 · cited 8× · PMID 38586504 · DOI 10.1017/s1366728923000391 -
Measurement of cross-language and cross-domain generalization following semantic feature-based anomia treatment in bilingual aphasia.
Russell-Meill M, Carpenter E, Marte MJ, Scimeca M, et al · · 2026 · cited 1× · PMID 40571559 · DOI 10.1080/09602011.2025.2522196 -
Predicting bilingual aphasia treatment outcomes using digital twins: a double-blind randomized controlled trial.
Kiran S, Carpenter E, Grasemann U, Scimeca M, et al · · 2026 · PMID 41963587 · DOI 10.1038/s41746-026-02583-9 -
The evolution of word retrieval errors during semantic feature-based therapy in bilingual aphasia.
Scimeca M, Peñaloza C, Carpenter E, Marte MJ, et al · · 2025 · PMID 41098414 · DOI 10.1017/s1366728925100370
Verify or expand the search:
- PubMed search for NCT02916524
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Semantic Feature Analysis (SFA)
Trials testing the same drug.
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Other recruiting trials for Aphasia
Currently open trials in the same condition.
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- NCT07281313 — Aphasia Physical EXercise Study: Randomized Trial · NA · recruiting
- NCT06990997 — Effects of Aphasia Identification Cards on Service Workers' Comprehension of People With Aphasia · NA · recruiting
- NCT06974279 — Post-Stroke Aphasia TMS · NA · recruiting
Other Boston University Charles River Campus trials
Trials by the same sponsor.
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- NCT06182241 — Identifying and Addressing Barriers to Retention in the Cervical Cancer Treatment Cascade Among Women With HIV in South · NA · not yet recruiting
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02916524 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Boston University Charles River Campus
- Last refreshed: 19 April 2021
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02916524.
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