NCT02915679: DOCS

Pain Perception in Suicidal Behavior Vulnerability

Terminated NA Last updated 11 January 2022

What this trial tests

NA trial testing Blood sample for genetic purpose, psychiatric assessment and pain investigation in Major Depressive Episode in 167 participants. Terminated before completion.

Timeline

17 June 2015

Primary endpoint
6 May 2021

6 May 2021

Quick facts

Lead sponsor	University Hospital, Montpellier
Phase	NA
Status	Terminated
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	other
Enrollment	167
Start date	17 June 2015
Primary completion	6 May 2021
Estimated completion	6 May 2021
Sites	1 location across France

Drugs / interventions tested

• Blood sample for genetic purpose, psychiatric assessment and pain investigation

Conditions studied

• Major Depressive Episode — all drugs for Major Depressive Episode →

Sponsor

University Hospital, Montpellier

Who can join

18 and older, any sex, with Major Depressive Episode. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

In France, almost 1 death on 50 is a suicide. The suicide occurs in unbearable psychic pain where mental trouble has a major influence. It is classified as preventable mortality. According to interpersonal psychological theory of suicide, the repeated exposition to stressful and painful events (as physical abuse) would facilitate suicide attempt through the increased pain tolerance. The social pain (or psychical pain on the broader sense) and physical pain are closely linked.

The investigators hypothesize that the measure of painful perception will be significantly superior on suicidals attempters compared to non-attempters. It will be the case for recent suicide attempters and former suicide attempters, suggesting a suicidal vulnerability trait. Moreover, the investigators expect that social distress induced by a social exclusion paradigm will be significantly superior on suicide attempters compared to non-attempters.

The aim of the study is to investigate the physical and psychic pain on depressed subjects with or without history of suicide attempts.

After a clinical evaluation (psychiatric symptomatology, personality trait, suicidal dimension), subjects will be submitted to a painful thermic stimulation and will participate at a computer test of social exclusion (named Cyberball).

Publications & conference data

1 peer-reviewed publication reference this trial (live from Europe PMC):

1. Targeting Psychological Pain After a Suicide Attempt: Scoping Review and Intervention Protocol.
   Comendador L, Palao DJ, Sanz A, Andreo-Jover J, et al · · 2026 · PMID 42074932 · DOI 10.3390/jcm15083124