NCT02913222

Movement Pattern Training in People With Intra-articular, Prearthritic Hip Disorders

Completed NA Results posted Last updated 27 March 2023

What this trial tests

NA trial testing Rehabilitation in Chronic Hip Joint Pain in 46 participants. Completed in 31 December 2019.

Timeline

4 February 2017

Primary endpoint
12 December 2018

31 December 2019

Quick facts

Lead sponsor	Washington University School of Medicine
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	46
Start date	4 February 2017
Primary completion	12 December 2018
Estimated completion	31 December 2019
Sites	2 locations across United States

Drugs / interventions tested

• Rehabilitation

Conditions studied

• Chronic Hip Joint Pain — all drugs for Chronic Hip Joint Pain →
• Prearthritic Hip Disease — all drugs for Prearthritic Hip Disease →

Sponsor

Washington University School of Medicine

Who can join

Adults 15 to 40, any sex, with Chronic Hip Joint Pain or Prearthritic Hip Disease. Patients with the condition only — healthy volunteers not accepted.

Results — posted to ClinicalTrials.gov

Per-arm endpoint measurements with 95% confidence intervals where reported. Source: trial results section.

Percentage of Participants Who Are Adherent to Treatment Attendance Primary · Immediately after treatment (13 weeks after baseline)

Percentage of study participants who attend 90% (9/10) of the supervised treatment sessions.

Group	Value	95% CI
Movement Pattern Training (MPT)	21
Standard Rehabilitation	22

Change in Function Using the Hip Disability and Osteoarthritis Outcome Score (HOOS) Activities in Daily Living Subscale From Baseline to Post-treatment (13 Weeks) Secondary · Immediately after treatment (13 weeks after baseline)

The Hip disability and Osteoarthritis Outcome Score (HOOS) is a patient reported outcome measure to quantify activity limitations due to hip pain. The outcome reported is the change (improvement) in function using the HOOS Activities in Daily Living subscale. Scoring of each subscale ranges from 0-100, with lower scores indicating greater impairment or activity limitation. Change was calculated by subtracting the baseline HOOS Activities in Daily Living from the post-treatment HOOS Activities in Daily Living .

Group	Value	95% CI
Movement Pattern Training (MPT)	12.5	± 11.0
Standard Rehabilitation	12.4	± 11.8

Change in Hip Disability and Osteoarthritis Outcome Score (HOOS) Symptoms Subscale From Baseline to Post-treatment (13 Weeks) Secondary · Immediately after treatment (13 weeks after baseline)

The Hip disability and Osteoarthritis Outcome Score (HOOS) is a patient reported outcome measure to quantify activity limitations due to hip pain. The outcome reported is the change (improvement) in function using the HOOSSymptoms subscale. Scoring of each subscale ranges from 0-100, with lower scores indicating greater impairment or activity limitation. Change was calculated by subtracting the baseline HOOSSymptoms from the post-treatment HOOSSymptoms.

Group	Value	95% CI
Movement Pattern Training (MPT)	15.0	± 13.2
Standard Rehabilitation	17.5	± 16.2

Change in Function Using the Hip Disability and Osteoarthritis Outcome Score (HOOS) Pain Subscale From Baseline to Post-treatment (13 Weeks) Secondary · Between Baseline and Immediately after treatment (13 weeks after baseline)

The Hip disability and Osteoarthritis Outcome Score (HOOS) is a patient reported outcome measure to quantify activity limitations due to hip pain. The outcome reported is the change (improvement) in function using the HOOS Pain subscale. Scoring of each subscale ranges from 0-100, with lower scores indicating greater impairment or activity limitation. Change was calculated by subtracting the baseline HOOS Pain from the post-treatment HOOS Pain.

Group	Value	95% CI
Movement Pattern Training (MPT)	18.1	± 12.9
Standard Rehabilitation	19.0	± 9.6

Change in Function Using the Hip Disability and Osteoarthritis Outcome Score (HOOS) Sport Subscale From Baseline to Post-treatment (13 Weeks) Secondary · Between Baseline and Immediately after treatment (13 weeks after baseline)

The Hip disability and Osteoarthritis Outcome Score (HOOS) is a patient reported outcome measure to quantify activity limitations due to hip pain. The outcome reported is the change (improvement) in function using the HOOS Sport subscale. Scoring of each subscale ranges from 0-100, with lower scores indicating greater impairment or activity limitation. Change was calculated by subtracting the baseline HOOS Sport from the post-treatment HOOS Sport.

Group	Value	95% CI
Movement Pattern Training (MPT)	24.4	± 18.1
Standard Rehabilitation	21.6	± 15.6

Change in Function Using the Hip Disability and Osteoarthritis Outcome Score (HOOS) Quality of Life (QOL) Subscale From Baseline to Post-treatment (13 Weeks) Secondary · Between Baseline and Immediately after treatment (13 weeks after baseline)

The Hip disability and Osteoarthritis Outcome Score (HOOS) is a patient reported outcome measure to quantify activity limitations due to hip pain. The outcome reported is the change (improvement) in function using the HOOS Quality of Life subscale. Scoring of each subscale ranges from 0-100, with lower scores indicating greater impairment or activity limitation. Change was calculated by subtracting the baseline HOOS Quality of Life from the post-treatment HOOS Quality of Life.

Group	Value	95% CI
Movement Pattern Training (MPT)	13.1	± 13.8
Standard Rehabilitation	20.9	± 16.6

Change in Function Using the Patient Specific Functional Scale From Baseline to Post-treatment (13 Weeks) Secondary · Between Baseline and Immediately after treatment (13 weeks after baseline)

The Patient Specific Functional Scale (PSFS), a patient-reported outcome measure of patient-specific activity limitations. Patients are asked to identify "3-5 activities you are unable to do or having difficulties performing due to the pain or symptoms in your hip". Patients then rated level of difficulty from 0-10, 0 indicating they are unable to perform the activity and 10 indicating they are able to perform the activity at their preinjury level. The final score is an average of all scores provided. Change was calculated by subtracting the baseline PSFS from the post-treatment PSFS.

Group	Value	95% CI
Movement Pattern Training (MPT)	1.7	± 1.7
Standard Rehabilitation	1.8	± 1.8

Change in Average Pain Intensity Quantified by a Numeric Pain Rating Scale (NPRS) From Baseline to Post-treatment (13 Weeks) Secondary · Between Baseline and Immediately after treatment (13 weeks after baseline)

The numeric pain rating scale (NPRS) is a patient-reported outcome measure of pain intensity quantified using a 0-10 scale, 0 indicating the patient perceives no pain and 10 indicating the patient perceives the pain to be "worst pain imaginable". For average NPRS, patients are asked to rate what their pain was over the last week. Change was calculated by subtracting the baseline average NPRS from the post-treatment average NPRS.

Group	Value	95% CI
Movement Pattern Training (MPT)	-2.9	± 1.5
Standard Rehabilitation	-2.5	± 1.9

Change in Worst Pain Intensity Quantified by a Numeric Pain Rating Scale (NPRS) From Baseline to Post-treatment (13 Weeks) Secondary · Between Baseline and Immediately after treatment (13 weeks after baseline)

The numeric pain rating scale (NPRS) is a patient-reported outcome measure of pain intensity quantified using a 0-10 scale, 0 indicating the patient perceives no pain and 10 indicating the patient perceives the pain to be "worst pain imaginable". For worst NPRS, patients are asked to rate what was their worst (highest) level of pain was over the last week. Change was calculated by subtracting the baseline worst NPRS from the post-treatment worst NPRS.

Group	Value	95% CI
Movement Pattern Training (MPT)	-3.7	± 1.8
Standard Rehabilitation	-3.9	± 3.0

Change in Function Using the Hip Disability and Osteoarthritis Outcome Score (HOOS) ADL Subscale From Baseline to 6 Months After Treatment Completion. Secondary · Between Baseline and 6 months after treatment completion

The Hip disability and Osteoarthritis Outcome Score (HOOS) is a patient reported outcome measure to quantify activity limitations due to hip pain. The outcome reported is the change (improvement) in function using the HOOS Activity Daily Living (ADL) subscale. Scoring of each subscale ranges from 0-100, with lower scores indicating greater impairment or activity limitation. Change was calculated by subtracting the baseline HOOSADL from the 6 month HOOSADL.

Group	Value	95% CI
Movement Pattern Training (MPT)	90.4	± 10.3
Standard Rehabilitation	92.9	± 8.7

Change in Function Using the Hip Disability and Osteoarthritis Outcome Score (HOOS) Symptoms Subscale From Baseline to 6 Months After Treatment Completion. Secondary · Between Baseline and 6 months after treatment completion

The Hip disability and Osteoarthritis Outcome Score (HOOS) is a patient reported outcome measure to quantify activity limitations due to hip pain. The outcome reported is the change (improvement) in function using the HOOS Symptoms subscale. Scoring of each subscale ranges from 0-100, with lower scores indicating greater impairment or activity limitation. Change was calculated by subtracting the baseline HOOSSymptom from the 6 month HOOSSymptom.

Group	Value	95% CI
Movement Pattern Training (MPT)	79.8	± 14.5
Standard Rehabilitation	84.0	± 12.3

Change in Function Using the Hip Disability and Osteoarthritis Outcome Score (HOOS) Pain Subscale From Baseline to 6 Months After Treatment Completion. Secondary · Between Baseline and 6 months after treatment completion

The Hip disability and Osteoarthritis Outcome Score (HOOS) is a patient reported outcome measure to quantify activity limitations due to hip pain. The outcome reported is the change (improvement) in function using the HOOS Pain subscale. Scoring of each subscale ranges from 0-100, with lower scores indicating greater impairment or activity limitation. Change was calculated by subtracting the baseline HOOSPain from the 6 month HOOSPain.

Group	Value	95% CI
Movement Pattern Training (MPT)	1.6	± 1.7
Standard Rehabilitation	1.6	± 2.0

Sponsor's own description

Intra-articular, prearthritic hip disorders (PAHD) result in substantial dysfunction in young adults and are proposed precursors to hip osteoarthritis (OA). Effective treatment of PAHD is needed to improve function in the young adult and prevent or delay the onset of hip OA, however evidence related to treatment of PAHD is limited. This research will provide the foundation for a future clinical trial to assess the efficacy of movement pattern training, an innovative rehabilitation approach for the treatment of PAHD.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

1. Movement pattern training compared with standard strengthening and flexibility among patients with hip-related groin pain: results of a pilot multicentre randomised clinical trial.
   Harris-Hayes M, Steger-May K, Bove AM, Foster SN, et al · · 2020 · cited 21× · PMID 32518674 · DOI 10.1136/bmjsem-2019-000707
2. One-year outcomes following physical therapist-led intervention for chronic hip-related groin pain: Ancillary analysis of a pilot multicenter randomized clinical trial.
   Harris-Hayes M, Steger-May K, M Bove A, Mueller MJ, et al · · 2021 · cited 7× · PMID 33458839 · DOI 10.1002/jor.24985
3. Comparison between movement pattern training and strengthening on muscle volume, muscle fat, and strength in patients with hip-related groin pain: An exploratory analysis.
   Koch K, Semciw AI, Commean PK, Hillen TJ, et al · · 2022 · cited 6× · PMID 34370330 · DOI 10.1002/jor.25158
4. Static Ankle Dorsiflexion and Hip and Pelvis Kinematics During Forward Step-Down in Patients With Hip-Related Groin Pain.
   Foster SN, Harris MD, Hastings MK, Mueller MJ, et al · · 2020 · cited 6× · PMID 33291065 · DOI 10.1123/jsr.2020-0140