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NCT02912104: POF
A Therapeutic Trial of Human Amniotic Epithelial Cells Transplantation for Primary Ovarian Failure
Phase 1 trial testing human amniotic epithelial cells (hAECs) transplantation in Primary Ovarian Insufficiency in 36 participants. Completed in 5 January 2023.
5 January 2022
Quick facts
| Lead sponsor | International Peace Maternity and Child Health Hospital |
|---|---|
| Phase | Phase 1 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 36 |
| Start date | 20 June 2020 |
| Primary completion | 5 January 2022 |
| Estimated completion | 5 January 2023 |
| Sites | 1 location across China |
Drugs / interventions tested
- human amniotic epithelial cells (hAECs) transplantation — full drug profile →
Conditions studied
- Primary Ovarian Insufficiency — all drugs for Primary Ovarian Insufficiency →
- Premature Ovarian Failure — all drugs for Premature Ovarian Failure →
- Infertility — all drugs for Infertility →
Sponsor
International Peace Maternity and Child Health Hospital
Who can join
Adults 18 to 45, female only, with Primary Ovarian Insufficiency or Premature Ovarian Failure. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
This project will clarify the safety and effectiveness of human amniotic epithelial cells transplantation for the treatment of primary ovarian failure (POF) patients and provide a new therapeutic method for patients with infertility.
Publications & conference data
8 peer-reviewed publications reference this trial (live from Europe PMC):
-
Applications of Human Amniotic Membrane for Tissue Engineering.
Fénelon M, Catros S, Meyer C, Fricain JC, et al · · 2021 · cited 83× · PMID 34070582 · DOI 10.3390/membranes11060387 -
Characteristics and Therapeutic Potential of Human Amnion-Derived Stem Cells.
Liu QW, Huang QM, Wu HY, Zuo GS, et al · · 2021 · cited 77× · PMID 33478081 · DOI 10.3390/ijms22020970 -
Application of human amniotic epithelial cells in regenerative medicine: a systematic review.
Zhang Q, Lai D. · · 2020 · cited 75× · PMID 33059766 · DOI 10.1186/s13287-020-01951-w -
Human Amniotic Epithelial Stem Cells: A Promising Seed Cell for Clinical Applications.
Qiu C, Ge Z, Cui W, Yu L, et al · · 2020 · cited 50× · PMID 33086620 · DOI 10.3390/ijms21207730 -
Amniotic fluid characteristics and its application in stem cell therapy: A review.
Shamsnajafabadi H, Soheili ZS. · · 2022 · cited 20× · PMID 36313262 · DOI 10.18502/ijrm.v20i8.11752 -
Human placenta-derived amniotic epithelial cells as a new therapeutic hope for COVID-19-associated acute respiratory distress syndrome (ARDS) and systemic inflammation.
Babajani A, Moeinabadi-Bidgoli K, Niknejad F, Rismanchi H, et al · · 2022 · cited 17× · PMID 35337387 · DOI 10.1186/s13287-022-02794-3 -
A Survey and Critical Evaluation of Isolation, Culture, and Cryopreservation Methods of Human Amniotic Epithelial Cells.
Naeem A, Gupta N, Arzoo N, Naeem U, et al · · 2022 · cited 9× · PMID 35289707 · DOI 10.1080/15384101.2021.2020015 -
Safety and efficacy of allogenic human amniotic epithelial cells transplantation via ovarian artery in patients with premature ovarian failure: a single-arm, phase 1 clinical trial.
Weng L, Wei L, Zhang Q, Sun T, et al · · 2024 · cited 8× · PMID 39165278 · DOI 10.1016/j.eclinm.2024.102744
Verify or expand the search:
- PubMed search for NCT02912104
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Primary Ovarian Insufficiency
Currently open trials in the same condition.
- NCT07357701 — Identifying Genome Variants in Non-Obstructive Azoospermia (NOA) or Primary Ovarian Insufficiency (POI) · recruiting
- NCT06357442 — Assessment of Endometrial Thickness Among Adolescent and Young Adult Patients on Estrogen Replacement Therapy Using Dail · recruiting
- NCT06167135 — Polycystic Ovary Syndrome, Mitochondrial Dysfunction, Obesity, Insulin Resistance Infertility (POMODORI) Cohort · recruiting
- NCT05327283 — Investigation of Copy Number Variations and Genetic Variants in POI · recruiting
Other International Peace Maternity and Child Health Hospital trials
Trials by the same sponsor.
- NCT07510139 — A Clinical Study of Umbilical Cord Mesenchymal Stem Cell-Derived Exosomes for the Treatment of Premature Ovarian Insuffi · Phase 1, PHASE2 · active not recruiting
- NCT06759480 — Study of Laparoscopic Radical Hysterectomy Based on Space Anatomy in Patients With IB3 and IIA2 Cervical Cancer · not yet recruiting
- NCT06599671 — Effectiveness of Transvaginal Niche Resection Versus Expectant Management in Patients with Secondary Infertility and a L · NA · not yet recruiting
- NCT07279181 — TVS, SHG, and MRI in Uterine Niche · completed
- NCT06006091 — The Effectiveness of the Letrozole-induced Endometrial Preparation Protocol in Frozen-thawed Embryo Transfer (FET) · NA · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02912104 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by International Peace Maternity and Child Health Hospital
- Last refreshed: 1 March 2023
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02912104.
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