A Biobank for Diaphragm Muscular Fiber (BOTAN)

NCT02900300 COMPLETED

This non-interventional study focuses on mechanical ventilation used in intensive care unit to supplement ventilatory function in patients. Mechanical ventilation can "paradoxically" be at the origin of complications that can be life-threatening in patients. This muscular pathology is called ventilation-induced diaphragmatic dysfunction (DDIV). Diaphragmatic muscle collected during a digestive surgery for a benign or malignant tumor of the liver requiring surgical excision in contact with the diaphragm from the care will be conserved. The diaphragm biopsy from the care will be retained for biobanking to obtain myoblast in culture which will differentiate in Diaphragm fiber. Then these fibers will be submitted under mechanical stress condition similar to those imposed in vivo by mechanical ventilation to validate in human a model in vitro of diaphragm dysfunction induced by mechanical ventilation. Then the second part of the study will be to evaluate with this model, the efficiency of an antioxidant therapy.

Details

Lead sponsor	University Hospital, Montpellier
Status	COMPLETED
Enrolment	12
Start date	Fri Feb 18 2022 00:00:00 GMT+0000 (Coordinated Universal Time)
Completion	Thu May 23 2024 00:00:00 GMT+0000 (Coordinated Universal Time)

Conditions

• Diaphragm Dysfunction
• Mechanical Ventilation

Countries

France