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NCT02881255: ATLAS S-ICD
Avoid Transvenous Leads in Appropriate Subjects
Completed
NA
Last updated 31 May 2022
What this trial tests
NA trial testing Implantable Cardioverter Defibrillator in Ventricular Arrhythmia in 544 participants. Completed in 10 February 2022.
Timeline
22 February 2017
Primary endpoint
31 January 2022
31 January 2022
10 February 2022
Quick facts
| Lead sponsor | Population Health Research Institute |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | prevention |
| Enrollment | 544 |
| Start date | 22 February 2017 |
| Primary completion | 31 January 2022 |
| Estimated completion | 10 February 2022 |
| Sites | 14 locations across Canada |
Drugs / interventions tested
- Implantable Cardioverter Defibrillator
Conditions studied
- Ventricular Arrhythmia — all drugs for Ventricular Arrhythmia →
Sponsor
Population Health Research Institute
Who can join
18 and older, any sex, with Ventricular Arrhythmia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The purpose of the study is to compare standard, single chamber transvenous ICD to sub-cutaneous ICD in occurrence of perioperative and long term device related complications and failed appropriate clinical shocks and arrhythmic death.
Publications & conference data
7 peer-reviewed publications reference this trial (live from Europe PMC):
-
Perioperative Safety and Early Patient and Device Outcomes Among Subcutaneous Versus Transvenous Implantable Cardioverter Defibrillator Implantations : A Randomized, Multicenter Trial.
Healey JS, Krahn AD, Bashir J, Amit G, et al · · 2022 · cited 46× · PMID 36343346 · DOI 10.7326/m22-1566 -
An Overview of Clinical Outcomes in Transvenous and Subcutaneous ICD Patients.
Baalman SWE, Quast ABE, Brouwer TF, Knops RE. · · 2018 · cited 15× · PMID 29992422 · DOI 10.1007/s11886-018-1021-8 -
The ATLAS Randomised Clinical Trial: What do the Superiority Results Mean for Subcutaneous ICD Therapy and Sudden Cardiac Death Prevention as a Whole?
Rordorf R. · · 2022 · cited 9× · PMID 36313240 · DOI 10.15420/aer.2022.11.s1 -
Cardiopulmonary Resuscitation and Defibrillator Use in Sports.
Carrington M, Providência R, Chahal CAA, D'Ascenzi F, et al · · 2022 · cited 4× · PMID 35242826 · DOI 10.3389/fcvm.2022.819609 -
Device-specific quality of life: results from the ATLAS trial-avoid transvenous leads in appropriate subjects.
Carroll SL, Mondésert B, Krahn AD, Bashir JG, et al · · 2024 · cited 2× · PMID 38695087 · DOI 10.1093/eurjcn/zvae067 -
Optimal Strategies for Mitigating Sudden Cardiac Death Risk in At-risk Patients with Structural Heart Disease.
Boey E, Kojodjojo P. · · 2018 · cited 1× · PMID 32494485 · DOI 10.19102/icrm.2018.090204 -
Transvenous versus subcutaneous implantable cardiac defibrillators for people at risk of sudden cardiac death
Iskandarani G, Khamis A, Sabra M, Cai M, et al · · 2020
Verify or expand the search:
- PubMed search for NCT02881255
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
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Related trials
Other trials of Implantable Cardioverter Defibrillator
Trials testing the same drug.
- NCT06269692 — MAgnetic Resonance Imaging-guided implanTation of Cardioverter DEFibrillators · NA · not yet recruiting
- NCT02656329 — International Study to Determine if AdreView Heart Function Scan Can be Used to Identify Patients With Mild or Moderate · Phase 3 · terminated
- NCT02121158 — Efficacy and Safety of Implantable Cardioverter-Defibrillator (ICD) Implantation in the Elderly · NA · terminated
Other recruiting trials for Ventricular Arrhythmia
Currently open trials in the same condition.
- NCT07201506 — Real-Time Intracardiac Echocardiography for Ventricular Arrhythmia Ablation · NA · recruiting
- NCT06964464 — Comparative Effectiveness of Carvedilol Versus Metoprolol Succinate in Heart Failure Patients With an Implantable Cardio · Phase 4 · recruiting
- NCT07517523 — Ventricular Arrhythmias in Acute Myocardial Infarction · recruiting
- NCT06730607 — Image-Based Prediction of Ventricular Tachycardias in Post-Myocarditis Patients: an International Multicenter Case-contr · recruiting
- NCT06730464 — Image-Based Prediction of Ventricular Tachycardia Events in Non-ischemic Cardiomyopathy · recruiting
Other Population Health Research Institute trials
Trials by the same sponsor.
- NCT07511543 — Glucagon-like Peptide-1 Receptor Agonists for Endovascular Stroke Thrombectomy · Phase 2 · not yet recruiting
- NCT07468448 — Combination Antithrombotic Treatment for Prevention of Recurrent Ischemic Stroke in IntraCranial Atherosclerotic diseaSe · Phase 3 · not yet recruiting
- NCT06587737 — Colchicine for the Reduction of Dependency and Vascular Events After an Acute Intracerebral Hemorrhage · Phase 3 · not yet recruiting
- NCT07011095 — DOAC or VKA in Patients With AF and Stroke While on DOAC - a Pilot Trial · EARLY_PHASE1 · not yet recruiting
- NCT06508164 — International CRDS Registry · recruiting
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
Data sources for this page
- Trial protocol + status: ClinicalTrials.gov NCT02881255 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Population Health Research Institute
- Last refreshed: 31 May 2022
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02881255.
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