NCT02881073: PARROT

Placental Growth Factor Assessment of Women With Suspected Pre-eclampsia

Completed NA Last updated 7 August 2019

What this trial tests

NA trial testing Maternal plasma PlGF quantification in Pre-eclampsia in 2,313 participants. Completed in 26 April 2019.

Timeline

29 June 2017

Primary endpoint
26 April 2019

26 April 2019

Quick facts

Lead sponsor	Irish Centre for Fetal and Neonatal Translational Research
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	crossover
Masking	none
Primary purpose	diagnostic
Enrollment	2,313
Start date	29 June 2017
Primary completion	26 April 2019
Estimated completion	26 April 2019
Sites	7 locations across Ireland

Drugs / interventions tested

• Maternal plasma PlGF quantification

Conditions studied

• Pre-eclampsia — all drugs for Pre-eclampsia →
• Pregnancy, High Risk — all drugs for Pregnancy, High Risk →
• Pregnancy Complications — all drugs for Pregnancy Complications →

Sponsor

Irish Centre for Fetal and Neonatal Translational Research

Who can join

18 and older, female only, with Pre-eclampsia or Pregnancy, High Risk. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The primary aim is to establish the effectiveness of plasma PlGF measurement in reducing maternal morbidity (with assessment of perinatal safety in parallel) in women presenting with suspected pre-eclampsia prior to 37 weeks' gestation.

The long term aim is to demonstrate that knowledge of PlGF measurement enables appropriate stratification of the antenatal management of women presenting with suspected pre-eclampsia, such that those at highest risk receive greater surveillance with a decrease in maternal adverse outcomes, and those at lower risk can be managed without unnecessary admission and other interventions, such that the results would influence international clinical practice in antenatal patient healthcare

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

1. Placental growth factor in assessment of women with suspected pre-eclampsia to reduce maternal morbidity: a stepped wedge cluster randomised control trial (PARROT Ireland).
   Hayes-Ryan D, Khashan AS, Hemming K, Easter C, et al · · 2021 · cited 17× · PMID 34389547 · DOI 10.1136/bmj.n1857
2. An exploration of women's experience of taking part in a randomized controlled trial of a diagnostic test during pregnancy: A qualitative study.
   Hayes-Ryan D, Meaney S, Nolan C, O'Donoghue K. · · 2020 · cited 8× · PMID 31578808 · DOI 10.1111/hex.12969
3. PARROT Ireland: Placental growth factor in Assessment of women with suspected pre-eclampsia to reduce maternal morbidity: a Stepped Wedge Cluster Randomised Control Trial Research Study Protocol.
   Hayes-Ryan D, Hemming K, Breathnach F, Cotter A, et al · · 2019 · cited 8× · PMID 30826791 · DOI 10.1136/bmjopen-2018-023562