Clinical And Microbiological Efficacy Of 4% Garcinia Mangostana L.Pericarp Gel As A Local Drug Delivery In The Treatment Of Chronic Periodontitis: A Randomized Controlled Clinical Trial

NCT02880397 NA COMPLETED

A single-center, randomized controlled clinical trial was done to assess the periodontal status of the individuals and the presence of red complex microorganisms (RCM) such as Treponema denticola, Porphyromonas.gingivalis and Tannerella.forsythia in the subgingival tissues of periodontal pockets at baseline followed by the application of mangostana gel as an adjunct to scaling and root planing. The periodontal parameters and RCM were again assessed at 3rd month and compared with the placebo group.

Details

Lead sponsor	Meenakshi Ammal Dental College and Hospital
Phase	NA
Status	COMPLETED
Enrolment	50
Start date	2015-08
Completion	2016-01

Conditions

• Generalized Chronic Periodontitis

Interventions

• Garcinia mangostana
• Placebo gel

Primary outcomes

• Clinical efficacy of 4% mangostana in chronic periodontitis patients from baseline to 3 months. — 3 months
  probing pocket depth was measured using Williams periodontal probe with the measurement of 0 to 9 mm and the criteria is as follows - 2 to 4 mm for gingivitis, 4 to 5 mm for slight periodontitis, 6 to 7 mm for moderate periodontitis and \> 7 mm for advanced periodontal disease. Clinical attachment level was measured from cemento-enamel junction to the base of the pocket using Williams periodontal probe with the criteria of 1 to 2 mm for slight periodontitis, 3 to 4 mm for moderate periodontits and greater or equal to 5 mm for severe periodontitis.