NCT02879656

Non-operative Treatment Versus Volar Locking Plate in Treatment of Distal Radius Fracture in Patients Over 65 Years

Completed NA Last updated 30 April 2025

What this trial tests

NA trial testing non-operative treatment in Distal Radius Fracture in 291 participants. Completed in 6 June 2023.

Timeline

23 February 2018

Primary endpoint
6 June 2023

6 June 2023

Quick facts

Lead sponsor	Tampere University Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	291
Start date	23 February 2018
Primary completion	6 June 2023
Estimated completion	6 June 2023
Sites	5 locations across Denmark, Finland, Sweden

Drugs / interventions tested

• non-operative treatment
• operative treatment

Conditions studied

• Distal Radius Fracture — all drugs for Distal Radius Fracture →

Sponsor

Tampere University Hospital

Who can join

65 and older, any sex, with Distal Radius Fracture. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The present collaboration study on the treatment of distal radius fractures is aimed to:

(i) to compare non-operative treatment to volar plating in the treatment of initially malaligned distal radius fractures in patients aged 65 and older in terms of functional outcome measured with PRWE

(ii) to compare non-operative treatment to volar plating in the treatment of distal radius fractures with early instability during follow-up, i.e., loss of reduction at 1 week (range 5 to 10 days) in patients aged 65 and older in terms of functional outcome measured with PRWE

(iii)to compare pain, disability, quality of life, grip strength, and the number of complications after non-operative treatment and the initial and delayed operative treatment of distal radius fracture

(iv) to assess the effect of pain catastrophizing score (PCS) on the functional outcome of non-operatively and operatively treated distal radius fracture

(v) to assess the association between physical activity and the number of wrist movements measured with Axivity accelerometer and functional outcome measured with PROMs of non-operatively and operatively treated distal radius fractures

(vi) to assess the effect of initial as well as the final radiological parameters on the functional outcome

(vii) to assess the correlation of probability of radiological malalignment estimated by clinical prediction rule (EWC) with functional outcome measured with PRWE and PASS

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Nordic Innovative Trial to Evaluate OsteoPorotic Fractures (NITEP-group): non-operative treatment versus surgery with volar locking plate in the treatment of distal radius fracture in patients aged 65 and over - a study protocol for a prospective, randomized controlled trial.
   Hevonkorpi TP, Launonen AP, Raittio L, Luokkala T, et al · · 2018 · cited 6× · PMID 29621979 · DOI 10.1186/s12891-018-2019-5
2. Nonoperative treatment versus volar locking plating for distal radius fracture in patients aged 65 years or older (DRIFT trial): A randomized controlled trial.
   Hevonkorpi TP, Launonen AP, Reito A, Schandorff Skjærbæk M, et al · · 2025 · PMID 40911648 · DOI 10.1371/journal.pmed.1004728