NCT02877277 (EVITA-Pilot) is a NA clinical trial of Vitamin C in Myelodysplastic Syndrome, sponsored by Rigshospitalet, Denmark.

Who is sponsoring NCT02877277?

NCT02877277 is sponsored by Rigshospitalet, Denmark.

What drugs are being tested in NCT02877277?

Interventions in NCT02877277: Vitamin C, Placebo.

What condition does NCT02877277 study?

NCT02877277 studies Myelodysplastic Syndrome, Acute Myeloid Leukemia.

Is NCT02877277 still recruiting?

NCT02877277 is currently completed. Last updated 24 September 2018.

Last reviewed 2018-09-24 · How we verify

NCT02877277: EVITA-Pilot

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Epigenetics, Vitamin C and Abnormal Hematopoiesis - Pilot Study

Completed NA Last updated 24 September 2018

What this trial tests

NA trial testing Vitamin C in Myelodysplastic Syndrome in 20 participants. Completed in 29 May 2017.

Timeline

8 August 2016

Primary endpoint
29 May 2017

29 May 2017

Quick facts

Lead sponsor	Rigshospitalet, Denmark
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	quadruple
Primary purpose	treatment
Enrollment	20
Start date	8 August 2016
Primary completion	29 May 2017
Estimated completion	29 May 2017
Sites	1 location across Denmark

Drugs / interventions tested

Vitamin C — full drug profile →
Placebo

Conditions studied

Myelodysplastic Syndrome — all drugs for Myelodysplastic Syndrome →
Acute Myeloid Leukemia — all drugs for Acute Myeloid Leukemia →

Sponsor

Rigshospitalet, Denmark

Who can join

18 and older, any sex, with Myelodysplastic Syndrome or Acute Myeloid Leukemia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

This study evaluates whether vitamin C improves responses to epigenetic therapy with DNMTis. Half of the patients will receive vitamin C and DNMTi while the other half will receive placebo and DNMTi.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

Epigenetics-targeted drugs: current paradigms and future challenges.
Dai W, Qiao X, Fang Y, Guo R, et al · · 2024 · cited 131× · PMID 39592582 · DOI 10.1038/s41392-024-02039-0
Interplay Among Metabolism, Epigenetic Modifications, and Gene Expression in Cancer.
Huo M, Zhang J, Huang W, Wang Y. · · 2021 · cited 68× · PMID 35004688 · DOI 10.3389/fcell.2021.793428
Oral vitamin C supplementation to patients with myeloid cancer on azacitidine treatment: Normalization of plasma vitamin C induces epigenetic changes.
Gillberg L, Ørskov AD, Nasif A, Ohtani H, et al · · 2019 · cited 66× · PMID 31623675 · DOI 10.1186/s13148-019-0739-5
Vitamin C Supplementation in the Treatment of Autoimmune and Onco-Hematological Diseases: From Prophylaxis to Adjuvant Therapy.
Isola S, Gammeri L, Furci F, Gangemi S, et al · · 2024 · cited 15× · PMID 39000393 · DOI 10.3390/ijms25137284
Repurposing Vitamin C for Cancer Treatment: Focus on Targeting the Tumor Microenvironment.
Li WN, Zhang SJ, Feng JQ, Jin WL. · · 2022 · cited 13× · PMID 35681589 · DOI 10.3390/cancers14112608
Role of Vitamin C in Targeting Cancer Stem Cells and Cellular Plasticity.
Lee Y. · · 2023 · cited 9× · PMID 38067361 · DOI 10.3390/cancers15235657
Unlocking the Heterogeneity in Acute Leukaemia: Dissection of Clonal Architecture and Metabolic Properties for Clinical Interventions.
Capelletti MM, Montini O, Ruini E, Tettamanti S, et al · · 2024 · cited 2× · PMID 39795903 · DOI 10.3390/ijms26010045
Unveiling vitamin C: A new hope in the treatment of diffuse large B‑cell lymphoma (Review).
Ren C, Li Y, Li M, Wang Y. · · 2025 · cited 1× · PMID 40314093 · DOI 10.3892/ijo.2025.5746

Verify or expand the search:

Other trials of Vitamin C

Trials testing the same drug.

NCT07476443 — Renoprotective Role of Vitamin C and Coenzyme Q10 in Nephrotoxicity · Phase 2, PHASE3 · not yet recruiting
NCT07414693 — Effect of Vitamin C on Length of Hospital Stay in Children With Severe Pneumonia · Phase 4 · recruiting
NCT06971315 — Impact of Vitamin C on Pain Detection and Tolerance Threshold · NA · completed
NCT06794255 — Exploratory Study on the Role of Vitamin C in Promoting Health in Middle-Aged and Elderly Adults · NA · recruiting
NCT07341308 — Does Vitamin C Increase the Body Heat Generated By The Nervous System? · NA · recruiting

Other recruiting trials for Myelodysplastic Syndrome

Currently open trials in the same condition.

NCT07020533 — A Vaccine (CMV-MVA Triplex Vaccine) for the Enhancement of CMV-Specific Immunity and the Prevention of CMV Viremia in Pa · Phase 1 · recruiting
NCT07422480 — A Study to Compare Elritercept With Epoetin Alfa to Treat Anemia in Adults With Very Low, Low, or Intermediate Risk Myel · Phase 3 · recruiting
NCT07107126 — Safety and Proof-of-Concept Study of RPT1G in Adults With Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndromes · Phase 1 · recruiting
NCT06781099 — Feasibility Trial of Extracorporeal Iron Purification in Patients With Myelodysplastic Syndrome or Myelofibrosis · NA · recruiting
NCT07285044 — The Cancer Connected Access and Remote Expertise Beyond Walls Program to Provide In-Home Cancer Treatment and Improve Tr · Phase 2 · recruiting

Other Rigshospitalet, Denmark trials

Trials by the same sponsor.

NCT07401368 — Clinicians' Trust in AI-Based Fetal Growth Estimates · NA · not yet recruiting
NCT07442357 — The Per-procedural Antibiotic Prophylaxis in Patients Undergoing Transcatheter Aortic Valve Implantation Trial · NA · not yet recruiting
NCT07528729 — Alcohol as a Modifiable Risk Factor for Atrial Fibrillation · NA · not yet recruiting
NCT07511439 — Reversible Effects of Oral Contraceptive Removal on Serotonergic Neurotransmission · Phase 4 · not yet recruiting
NCT07467187 — Invasive Home Ventilation in Denmark · not yet recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02877277 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Rigshospitalet, Denmark
Last refreshed: 24 September 2018

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02877277.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing