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NCT02872922
Effects of Low Intensity Therapeutic Ultrasound on Endothelial Function
NA trial testing Low intensity therapeutic ultrasound in Diabetes Mellitus, Type 2 in 22 participants. Completed in 20 September 2017.
20 September 2017
Quick facts
| Lead sponsor | Universidade Federal de Santa Maria |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | crossover |
| Masking | triple |
| Primary purpose | basic science |
| Enrollment | 22 |
| Start date | 10 December 2016 |
| Primary completion | 20 September 2017 |
| Estimated completion | 20 September 2017 |
| Sites | 1 location across Brazil |
Drugs / interventions tested
- Low intensity therapeutic ultrasound
Conditions studied
- Diabetes Mellitus, Type 2 — all drugs for Diabetes Mellitus, Type 2 →
Sponsor
Universidade Federal de Santa Maria — full company profile →
Who can join
Adults 25 to 65, any sex, with Diabetes Mellitus, Type 2. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Endothelium is a cell layer that interposes blood and smooth muscle of vessels. This biological sensor reacts to physical and chemical stimuli by synthesis and/or liberation of regulatory substances like nitric oxide (NO), which acts on vascular tone, growth of muscle cells and platelet aggregation and leukocyte. Clinically, endothelial function measured by technique flow-mediated dilation (FMD) is a strong predictor of cardiovascular events and all-cause mortality. Previo study demonstrated that continuous and pulsed therapeutic 1-MHz ultrasound waveforms improved endothelial function in health volunteers and this vasodilation persisted for 20 min, which provided them with anti-inflammatory vascular effects. In subjects with type 2 diabetes (DM2) the chronical hyperglycemia and dyslipidemia reduce NO bioavailability causing endothelial dysfunction. Low intensity therapeutic ultrasound is an electrotherapeutic instrument employed in musculoskeletal injuries that promotes endothelium-dependent vasodilation, and its mechanism of action has not been studied on DM2. The aim of our study is evaluate endothelial function of patients with DM2 after different waveforms (placebo, continuous and pulsed) of therapeutic ultrasound. Therapeutic ultrasound is a electrotherapeutic instrument that can changes arterial endothelial function of subjects with DM2 because of NO bioavailability increasing, which implies anti-inflammatory and vasodilatory beneficial alterations for diabetic patients.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Ultrasound Therapy: Experiences and Perspectives for Regenerative Medicine.
de Lucas B, Pérez LM, Bernal A, Gálvez BG. · · 2020 · cited 38× · PMID 32957737 · DOI 10.3390/genes11091086
Verify or expand the search:
- PubMed search for NCT02872922
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other recruiting trials for Diabetes Mellitus, Type 2
Currently open trials in the same condition.
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- NCT07242469 — A Clinical Trial of MK-1403 in Participants With Type 2 Diabetes Mellitus (MK-1403-006) · Phase 1 · recruiting
- NCT07444203 — Transformative Research in Diabetic Nephropathy 2.0 · recruiting
Other Universidade Federal de Santa Maria trials
Trials by the same sponsor.
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- NCT05948722 — Behavioral Intervention Program Based on Motivational Interview · NA · active not recruiting
- NCT06371287 — Effect of Musical Auditory Training on Subjects With Tinnitus Disorder · NA · recruiting
- NCT04418700 — Effects of the Breath Stacking Technique After Upper Abdominal Surgery · NA · completed
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02872922 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Universidade Federal de Santa Maria
- Last refreshed: 21 September 2017
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02872922.
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