NCT02868385 (RePST) is a Phase 3 clinical trial of 4x Praziquantel in Schistosomiasis, sponsored by Leiden University Medical Center.

Who is sponsoring NCT02868385?

NCT02868385 is sponsored by Leiden University Medical Center.

What drugs are being tested in NCT02868385?

Interventions in NCT02868385: 4x Praziquantel, 1x Praziquantel.

What condition does NCT02868385 study?

NCT02868385 studies Schistosomiasis.

Is NCT02868385 still recruiting?

NCT02868385 is currently completed. Last updated 18 November 2020.

Last reviewed 2020-11-18 · How we verify

NCT02868385: RePST

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Repeated Doses of Praziquantel in Schistosomiasis Treatment (RePST)

Completed Phase 3 Last updated 18 November 2020

What this trial tests

Phase 3 trial testing 4x Praziquantel in Schistosomiasis in 167 participants. Completed in 14 January 2019.

Timeline

1 October 2018

Primary endpoint
14 January 2019

14 January 2019

Quick facts

Lead sponsor	Leiden University Medical Center
Phase	Phase 3
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	167
Start date	1 October 2018
Primary completion	14 January 2019
Estimated completion	14 January 2019
Sites	1 location across Côte d’Ivoire

Drugs / interventions tested

4x Praziquantel — full drug profile →
1x Praziquantel — full drug profile →

Conditions studied

Schistosomiasis — all drugs for Schistosomiasis →

Sponsor

Leiden University Medical Center

Who can join

Adults 5 to 18, any sex, with Schistosomiasis. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

An open label, randomized controlled trial of single vs. multiple treatments of praziquantel in intestinal African schistosomiasis in Côte d'Ivoire This study aims to determine the efficacy of repeated (up to four times) praziquantel treatment against S. mansoni infection in school-age children from Côte d'Ivoire using the traditional Kato-Katz thick smear technique, but also with more accurate and non-invasive antigen- and DNA-detection methods.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Efficacy of single versus four repeated doses of praziquantel against Schistosoma mansoni infection in school-aged children from Côte d'Ivoire based on Kato-Katz and POC-CCA: An open-label, randomised controlled trial (RePST).
Hoekstra PT, Casacuberta-Partal M, van Lieshout L, Corstjens PLAM, et al · · 2020 · cited 22× · PMID 32196506 · DOI 10.1371/journal.pntd.0008189
Limited efficacy of repeated praziquantel treatment in Schistosoma mansoni infections as revealed by highly accurate diagnostics, PCR and UCP-LF CAA (RePST trial).
Hoekstra PT, Casacuberta-Partal M, van Lieshout L, Corstjens PLAM, et al · · 2022 · cited 15× · PMID 36548444 · DOI 10.1371/journal.pntd.0011008
Repeated doses of Praziquantel in Schistosomiasis Treatment (RePST) - single versus multiple praziquantel treatments in school-aged children in Côte d'Ivoire: a study protocol for an open-label, randomised controlled trial.
Hoekstra PT, Casacuberta Partal M, Amoah AS, van Lieshout L, et al · · 2018 · cited 6× · PMID 30547750 · DOI 10.1186/s12879-018-3554-2

Verify or expand the search:

Other recruiting trials for Schistosomiasis

Currently open trials in the same condition.

NCT07358910 — Risk Assessment of Community Spread of Multiple Endemic Infectious Diseases in a One Health Perspective · recruiting
NCT06560853 — Evaluation of a Comprehensive School Health Programme in Zambia · NA · active not recruiting

Other Leiden University Medical Center trials

Trials by the same sponsor.

NCT07312565 — Occurrence of Abdominal Aortic Aneurysms in Patients With Aneurysmal Subarachnoid Hemorrhage · not yet recruiting
NCT07090343 — Semaglutide in Patients Undergoing Transcatether Aortic Valve Replacement · Phase 3 · not yet recruiting
NCT07498738 — Making Diabetes Care Fit for Young Adults Living With Type 1 Diabetes: Observations, Reflections and Expert Opinions · NA · not yet recruiting
NCT06545292 — Microsampling for Therapeutic Drug Monitoring of Oral Oncolytics in Oncology Patients · NA · recruiting
NCT07021495 — SKIN Disease Profiling by an Exploratory, pRospective, Biomarker Study in dermatoloGY Practice (SKINERGY) · recruiting

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02868385 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Leiden University Medical Center
Last refreshed: 18 November 2020

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02868385.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing