Postoperative Oxycodone Consumption After Spinal Surgery in Pregabalin-treated Patients Compared to a 48-h Perioperative Administration: a Prospective, Observational Study (PREGAB)

NCT02866396 COMPLETED

Spinal surgery is associated with intense pain and associated to a history of preoperative chronic pain. Pregabalin is licensed to treat chronic neuropathic pain, particularly when high dose of opioid are required. Preoperative pain is associated with high postoperative pain scores and opioid requirement promoting persistent hyperalgesic state. The investigators will evaluate the postoperative opioid consumption and pain scores in patients scheduled for lumbar surgery and taking pregabalin since more than 15 days and compare with preoperative pregabalin-free patient that will receive pregabalin only during surgery.

Details

Lead sponsor	Christophe Aveline, MD
Status	COMPLETED
Enrolment	70
Start date	2016-09
Completion	2017-12

Conditions

• Postoperative Pain
• Neuropathic Pain

Interventions

• Pregabalin
• Naive patient

Primary outcomes

• Oxycodone consumption — 24h postoperatively
  mg

Countries

France