Last reviewed · How we verify
Conservative Treatments of Retinoblastoma (RETINO2011)
Conservative treatments of retinoblastoma (RETINO 2011) 1. -Multicentric non randomised, phase II study for the patients treated by chemoreduction (VP16, carboplatin) followed by chemothermotherapy without laser treatment at day 8 2. -Multicentric non randomised, phase II study for the patients with bilateral very asymmetric dis-ease (Group D eye on one of the eye) or unilateral presentation groups B/C/D according to the age and vitreous seeding 3. \- Multicentric non randomised, phase II study for the patients treated by 6 cycles of three drugs regimen and local treatments for bilateral group D eyes or on the only eye.
Details
| Lead sponsor | Institut Curie |
|---|---|
| Phase | Phase 2 |
| Status | ACTIVE_NOT_RECRUITING |
| Enrolment | 133 |
| Start date | 2012-02 |
| Completion | 2035-09 |
Conditions
- Retinoblastoma
- Children
- Retinal Neoplasm
Interventions
- VP16, carboplatin
- Melphalan
- VP16, carboplatin, vincristin
- Carboplatin + laser day 1 (chemothermotherapy)
- Laser (local treatment)
- cryoapplication (local treatment)
- I125 radioactive plaques (local treatment)
- intravitreal Melphalan (local treatment)
Primary outcomes
- Rate of enucleation and external beam irradiation — From first day of treatment to 18 months after the end of treatments
Countries
France