NCT02855346 (DAP/LNG) is a Phase 1 clinical trial of 200 mg of DPV + 320 mg LNG in HIV Prevention, sponsored by International Partnership for Microbicides, Inc..

Who is sponsoring NCT02855346?

NCT02855346 is sponsored by International Partnership for Microbicides, Inc..

What drugs are being tested in NCT02855346?

Interventions in NCT02855346: 200 mg of DPV + 320 mg LNG, 200 mg of DPV.

What condition does NCT02855346 study?

NCT02855346 studies HIV Prevention.

Is NCT02855346 still recruiting?

NCT02855346 is currently completed. Last updated 22 May 2018.

Last reviewed 2018-05-22 · How we verify

NCT02855346: DAP/LNG

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

PK and Safety Study of Vaginal Rings Containing Dapivirine and Levonorgestrel

Completed Phase 1 Last updated 22 May 2018

What this trial tests

Phase 1 trial testing 200 mg of DPV + 320 mg LNG in HIV Prevention in 24 participants. Completed in 18 August 2017.

Timeline

3 May 2017

Primary endpoint
18 August 2017

18 August 2017

Quick facts

Lead sponsor	International Partnership for Microbicides, Inc.
Phase	Phase 1
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	single group
Masking	none
Primary purpose	prevention
Enrollment	24
Start date	3 May 2017
Primary completion	18 August 2017
Estimated completion	18 August 2017
Sites	2 locations across United States

Drugs / interventions tested

200 mg of DPV + 320 mg LNG
200 mg of DPV

Conditions studied

HIV Prevention — all drugs for HIV Prevention →

Sponsor

International Partnership for Microbicides, Inc. — full company profile →

Who can join

Adults 18 to 45, female only, with HIV Prevention. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

PK and Safety Study of Vaginal Ring Containing Dapivirine and Levonorgestrel

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

Acceptability of a dapivirine levonorgestrel vaginal ring in two Phase 1 trials (MTN-030/IPM 041 and MTN-044/IPM 053/CCN019): Implications for multipurpose prevention technology development.
Friedland BA, Gundacker H, Achilles SL, Chen BA, et al · · 2025 · cited 4× · PMID 39808648 · DOI 10.1371/journal.pone.0312957
Phase 1 randomized trials to assess safety, pharmacokinetics, and vaginal bleeding associated with use of extended duration dapivirine and levonorgestrel vaginal rings.
Achilles SL, Kelly CW, Hoesley CJ, Blithe DL, et al · · 2024 · cited 4× · PMID 38838028 · DOI 10.1371/journal.pone.0304552

Verify or expand the search:

Other recruiting trials for HIV Prevention

Currently open trials in the same condition.

NCT07194902 — HIV Self-testing for Partners of HIV-uninfected Postpartum Women · NA · recruiting
NCT07218211 — Enhancing PrEP Uptake and Retention Among Latine TGW and GBM in the South Using Long-Acting Injectable PrEP · Phase 4 · recruiting
NCT07349758 — Evaluation of Single Dosing With Two F/TAF Tablets Among Healthy Volunteers · Phase 1 · recruiting
NCT07433985 — California MEPS Hub · NA · recruiting
NCT07002866 — Suubi4PrEP: Improving PrEP Access and Adherence Among Adolescent Girls and Young Women in Uganda · NA · recruiting

Other International Partnership for Microbicides, Inc. trials

Trials by the same sponsor.

NCT05416021 — Relative Bioavailability Trial of Dapivirine Ring-004 and Ring-008 · Phase 1 · completed
NCT05041699 — PK, Safety Study of 90-Day Use of Vaginal Rings Containing Dapivirine and Levonorgestrel · Phase 1 · completed
NCT03467347 — PK Study of 90-Day Use of Vaginal Rings Containing Dapivirine and Levonorgestrel · Phase 1 · completed
NCT03234400 — A Phase 1, Randomized Pharmacokinetics and Safety Study of Extended Duration Dapivirine Vaginal Rings · Phase 1 · completed
NCT02858037 — Trial to Assess the Continued Safety of and Adherence to a Vaginal Ring Containing Dapivirine in Women · Phase 3 · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02855346 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by International Partnership for Microbicides, Inc.
Last refreshed: 22 May 2018

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02855346.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing