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NCT02844335
Combination of Cryosurgery and NK Immunotherapy for Advanced Breast Cancer
Completed
Phase 1, PHASE2
Last updated 12 September 2019
What this trial tests
Phase 1, PHASE2 trial testing Cryosurgery in Breast Cancer Recurrent in 60 participants. Completed in 1 July 2019.
Timeline
1 July 2016
Primary endpoint
1 July 2017
1 July 2017
1 July 2019
Quick facts
| Lead sponsor | Fuda Cancer Hospital, Guangzhou |
|---|---|
| Phase | Phase 1, PHASE2 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | none |
| Primary purpose | treatment |
| Enrollment | 60 |
| Start date | 1 July 2016 |
| Primary completion | 1 July 2017 |
| Estimated completion | 1 July 2019 |
| Sites | 1 location across China |
Drugs / interventions tested
- Cryosurgery
- NK immunotherapy — full drug profile →
Conditions studied
- Breast Cancer Recurrent — all drugs for Breast Cancer Recurrent →
Sponsor
Fuda Cancer Hospital, Guangzhou
Who can join
Adults 30 to 70, any sex, with Breast Cancer Recurrent. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The aim of this study is the safety and efficacy of cryosurgery plus NK immunotherapy to advanced breast cancer.
Publications & conference data
8 peer-reviewed publications reference this trial (live from Europe PMC):
-
NK cell-based cancer immunotherapy: from basic biology to clinical development.
Liu S, Galat V, Galat Y, Lee YKA, et al · · 2021 · cited 504× · PMID 33407739 · DOI 10.1186/s13045-020-01014-w -
Influence of the Tumor Microenvironment on NK Cell Function in Solid Tumors.
Melaiu O, Lucarini V, Cifaldi L, Fruci D. · · 2019 · cited 324× · PMID 32038612 · DOI 10.3389/fimmu.2019.03038 -
Immunotherapeutic interventions of Triple Negative Breast Cancer.
Li Z, Qiu Y, Lu W, Jiang Y, et al · · 2018 · cited 99× · PMID 29848327 · DOI 10.1186/s12967-018-1514-7 -
Cryoablation and Immunotherapy: An Enthralling Synergy to Confront the Tumors.
Yakkala C, Chiang CL, Kandalaft L, Denys A, et al · · 2019 · cited 67× · PMID 31608067 · DOI 10.3389/fimmu.2019.02283 -
Trial Watch: Adoptively transferred cells for anticancer immunotherapy.
Fournier C, Martin F, Zitvogel L, Kroemer G, et al · · 2017 · cited 55× · PMID 29147628 · DOI 10.1080/2162402x.2017.1363139 -
Photodynamic Therapy and Hyperthermia in Combination Treatment-Neglected Forces in the Fight against Cancer.
Bienia A, Wiecheć-Cudak O, Murzyn AA, Krzykawska-Serda M. · · 2021 · cited 36× · PMID 34452108 · DOI 10.3390/pharmaceutics13081147 -
The Advantages and Challenges of Anticancer Dendritic Cell Vaccines and NK Cells in Adoptive Cell Immunotherapy.
Abakushina EV, Popova LI, Zamyatnin AA, Werner J, et al · · 2021 · cited 29× · PMID 34835294 · DOI 10.3390/vaccines9111363 -
Killers at the crossroads: The use of innate immune cells in adoptive cellular therapy of cancer.
Sabry M, Lowdell MW. · · 2020 · cited 21× · PMID 32416056 · DOI 10.1002/sctm.19-0423
Verify or expand the search:
- PubMed search for NCT02844335
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of Cryosurgery
Trials testing the same drug.
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- NCT04249167 — Cryoablation, Atezolizumab/Nab-paclitaxel for Locally Advanced or Metastatic Triple Negative Breast Cancer · EARLY_PHASE1 · withdrawn
- NCT04150939 — Cryoablation for the Treatment of Metastatic Cancer · NA · active not recruiting
Other recruiting trials for Breast Cancer Recurrent
Currently open trials in the same condition.
- NCT06799065 — First-in-Human Study of ATX-295, an Oral Inhibitor of KIF18A, in Patients With Advanced or Metastatic Solid Tumors, Incl · Phase 1 · recruiting
- NCT06659146 — Thermotherapy in Addition to SOC Palliative Radiotherapy · NA · recruiting
- NCT06458413 — Utidelone Capsule Plus Capecitabine (CAP) for Metastatic Breast Cancer · Phase 2 · recruiting
- NCT05592938 — Partial Breast Re-irradiation Using Ultra Hypofractionation (PRESERVE) · NA · recruiting
- NCT05730608 — 18F-FDG PET/CT Imaging for Breast Cancer · NA · recruiting
Other Fuda Cancer Hospital, Guangzhou trials
Trials by the same sponsor.
- NCT04393220 — Combination of PD-1 and VEGFR-2 Blockade for Advanced Hepatocellular Carcinoma · Phase 2 · completed
- NCT03673137 — Phase II/III of Randomized Controlled Clinical Research on IRE Synchronous Chemotherapy for LAPC · Phase 2, PHASE3 · completed
- NCT03976206 — Very Small Embryonic-like Stem Cells for Facial Skin Antiaging · Phase 1, PHASE2 · withdrawn
- NCT03975101 — Very Small Embryonic-like Stem Cells for Knee Osteoarthritis · Phase 1, PHASE2 · withdrawn
- NCT03985462 — Very Small Embryonic-like Stem Cells for Ovary · Phase 1, PHASE2 · withdrawn
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
Data sources for this page
- Trial protocol + status: ClinicalTrials.gov NCT02844335 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Fuda Cancer Hospital, Guangzhou
- Last refreshed: 12 September 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02844335.
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