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NCT02822404: CysPed

Description of the Cystatin C as an Early Nephrotoxic Bio-marker in Pediatric Oncology

Completed NA Last updated 1 April 2026
What this trial tests

NA trial testing Urinary and blood sample for Cystatine dosage in Kidney Diseases in 42 participants. Completed in 4 May 2021.

Timeline
17 February 2012
Primary endpoint
4 May 2021
4 May 2021

Quick facts

Lead sponsorUniversity Hospital, Toulouse
PhaseNA
StatusCompleted
Study typeINTERVENTIONAL
Allocationna
Designsingle group
Maskingnone
Primary purposediagnostic
Enrollment42
Start date17 February 2012
Primary completion4 May 2021
Estimated completion4 May 2021
Sites1 location across France

Drugs / interventions tested

Conditions studied

Sponsor

University Hospital, Toulouse

Who can join

Under 18, any sex, with Kidney Diseases. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Cisplatin and ifosfamide are commonly used drugs in chemotherapy. They are known to involve renal toxic threats in children given their immature kidney. This toxicity is increased especially after nephrectomy and/or concomitant radiotherapy. In pediatric oncology, the available evaluation methods of the renal function could be very restrictive to perform on children. In this study, the investigators intend to test the use of the cystatin C as an effective and reliable biological marker of renal toxicity in children treated with cisplatin and / or ifosfamide.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

  1. Nephrotoxicity in cancer treatment: An update.
    Chen C, Xie D, Gewirtz DA, Li N. · · 2022 · cited 18× · PMID 35779877 · DOI 10.1016/bs.acr.2022.03.005
  2. Plasma cystatin C is a marker of renal glomerular injury in children treated with cisplatin or ifosfamide.
    Lambert M, White-Koning M, Alonso M, Garnier A, et al · · 2021 · cited 6× · PMID 33058496 · DOI 10.1002/pbc.28747
  3. A population pharmacokinetic approach to compare <sup>51</sup>Cr-EDTA and <sup>99 m</sup>Tc-DTPA clearances in measuring renal glomerular filtration rate in oncopediatrics.
    Gracia M, Ankaoua V, Alonso M, Pasquet M, et al · · 2025 · cited 1× · PMID 40439777 · DOI 10.1007/s00467-025-06828-9

Verify or expand the search:

Other recruiting trials for Kidney Diseases

Currently open trials in the same condition.

Other University Hospital, Toulouse trials

Trials by the same sponsor.

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Data sources for this page

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02822404.

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