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NCT02822404: CysPed
Description of the Cystatin C as an Early Nephrotoxic Bio-marker in Pediatric Oncology
NA trial testing Urinary and blood sample for Cystatine dosage in Kidney Diseases in 42 participants. Completed in 4 May 2021.
4 May 2021
Quick facts
| Lead sponsor | University Hospital, Toulouse |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | na |
| Design | single group |
| Masking | none |
| Primary purpose | diagnostic |
| Enrollment | 42 |
| Start date | 17 February 2012 |
| Primary completion | 4 May 2021 |
| Estimated completion | 4 May 2021 |
| Sites | 1 location across France |
Drugs / interventions tested
- Urinary and blood sample for Cystatine dosage
Conditions studied
- Kidney Diseases — all drugs for Kidney Diseases →
Sponsor
University Hospital, Toulouse
Who can join
Under 18, any sex, with Kidney Diseases. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Cisplatin and ifosfamide are commonly used drugs in chemotherapy. They are known to involve renal toxic threats in children given their immature kidney. This toxicity is increased especially after nephrectomy and/or concomitant radiotherapy. In pediatric oncology, the available evaluation methods of the renal function could be very restrictive to perform on children. In this study, the investigators intend to test the use of the cystatin C as an effective and reliable biological marker of renal toxicity in children treated with cisplatin and / or ifosfamide.
Publications & conference data
3 peer-reviewed publications reference this trial (live from Europe PMC):
-
Nephrotoxicity in cancer treatment: An update.
Chen C, Xie D, Gewirtz DA, Li N. · · 2022 · cited 18× · PMID 35779877 · DOI 10.1016/bs.acr.2022.03.005 -
Plasma cystatin C is a marker of renal glomerular injury in children treated with cisplatin or ifosfamide.
Lambert M, White-Koning M, Alonso M, Garnier A, et al · · 2021 · cited 6× · PMID 33058496 · DOI 10.1002/pbc.28747 -
A population pharmacokinetic approach to compare <sup>51</sup>Cr-EDTA and <sup>99 m</sup>Tc-DTPA clearances in measuring renal glomerular filtration rate in oncopediatrics.
Gracia M, Ankaoua V, Alonso M, Pasquet M, et al · · 2025 · cited 1× · PMID 40439777 · DOI 10.1007/s00467-025-06828-9
Verify or expand the search:
- PubMed search for NCT02822404
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02822404 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by University Hospital, Toulouse
- Last refreshed: 1 April 2026
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02822404.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing