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Evaluation of Aerosolized Drugs Deposition Delivered Through a Mechanical Ventilator
Aerosol delivery through a ventilator is influenced by numerous factors from ventilator-related, circuit-related to device-related factors. Aerosolized drug delivery through a ventilator system was studied on bench model with albuterol, yet the results were often overestimated. The objective of this study was to evaluate inhaled bronchodilator and mucolytic agents delivered through a ventilator system.
Details
| Lead sponsor | Chang Gung University |
|---|---|
| Phase | NA |
| Status | COMPLETED |
| Enrolment | 30 |
| Start date | 2016-06 |
| Completion | 2016-12-31 |
Conditions
- Chronic Obstructive Pulmonary Disease
Interventions
- Salbutamol
- Acetylcysteine
Primary outcomes
- Inhaled drug dose — Inhaled drug dose was collected Immediately after each nebulization, expected average of 20 minutes
Drug depositions in inspiratory filters were analyzed by a spectrophotometer.
Countries
Taiwan