NCT02809261

The Effect of Perineural Injection Therapy in Patients With Carpal Tunnel Syndrome

Completed NA Last updated 19 December 2017

What this trial tests

NA trial testing Ultrasound-guided perineural injection with 5% dextrose in Carpal Tunnel Syndrome in 60 participants. Completed in 30 March 2017.

Timeline

1 May 2016

Primary endpoint
30 March 2017

30 March 2017

Quick facts

Lead sponsor	Tri-Service General Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	60
Start date	1 May 2016
Primary completion	30 March 2017
Estimated completion	30 March 2017
Sites	1 location across Taiwan

Drugs / interventions tested

• Ultrasound-guided perineural injection with 5% dextrose
• Ultrasound-guided perineural injection with normal saline
• Normal Saline
• 5% Dextrose — full drug profile →

Conditions studied

• Carpal Tunnel Syndrome — all drugs for Carpal Tunnel Syndrome →

Sponsor

Tri-Service General Hospital

Who can join

Adults 20 to 85, any sex, with Carpal Tunnel Syndrome. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Carpal tunnel syndrome (CTS) is the most common peripheral entrapment neuropathy with involving compression of the median nerve in the carpal tunnel. Rather than other progressive disease, CTS is characterized by remission and recurrence. Although many conservative managements of CTS, the effectiveness of these methods is insignificant or only persist for a short duration. Recently, the ultrasound-guided perineural injection with 5% dextrose was widely used for entrapment neuropathy with positive benefit. However, current studies have not entirely proved the effects of perineural injection on peripheral neuropathy because these studies enrolled small number of patients and lacked controlled design. The investigators design a randomized, double-blind, controlled trail to assess the effect after ultrasound-guided perineural injection with 5% dextrose in patients with CTS.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Six-month Efficacy of Perineural Dextrose for Carpal Tunnel Syndrome: A Prospective, Randomized, Double-Blind, Controlled Trial.
   Wu YT, Ho TY, Chou YC, Ke MJ, et al · · 2017 · cited 86× · PMID 28778254 · DOI 10.1016/j.mayocp.2017.05.025
2. Efficacy and safety of platelet-rich plasma in the treatment of carpal tunnel syndrome: A network meta-analysis of different injection treatments.
   Hong P, Zheng Y, Rai S, Ding Y, et al · · 2022 · cited 8× · PMID 36438824 · DOI 10.3389/fphar.2022.906075