NCT02799004

How Much Opioids Do You Need After Your Emergency Department Visit

Completed Last updated 31 March 2026

What this trial tests

trial in Acute Pain in 761 participants. Completed in 30 September 2018.

Timeline

7 June 2016

Primary endpoint
30 September 2017

30 September 2018

Quick facts

Lead sponsor	Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal
Status	Completed
Study type	OBSERVATIONAL
Enrollment	761
Start date	7 June 2016
Primary completion	30 September 2017
Estimated completion	30 September 2018
Sites	1 location across Canada

Conditions studied

• Acute Pain — all drugs for Acute Pain →

Sponsor

Centre Integre Universitaire de Sante et Services Sociaux du Nord de l'ile de Montreal — full company profile →

Who can join

18 and older, any sex, with Acute Pain. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Pain is one of the most common complaints in emergency department (ED) and is still often poorly managed. A major prospective multicenter study reported that 74% of patients that had a pain complaint at ED triage are discharged in moderate to severe pain. Accordingly, physicians frequently prescribed analgesic after discharged for these patients, and opioid is given in 29% of ED visits involving pain complaints. However, few studies evaluate pain management after ED discharge: the frequency and length of opioids prescriptions, the opioids quantity taken by the patients, are the patients relieved and satisfied by these pain treatments, what are the adverse effects associated with the use of these medications, and what are the chances of developing addiction?

The primary aim of this study is to determine the required minimal opioids prescription for patients treated for acute pain after being discharge from the ED. Secondary objectives include: 1) monitor the patients' adverse events during opioids treatment; 2) evaluate the patients' level of pain relief associated with their respective opioids treatment; 3) determine the patients' level of addiction following post-ED opioids treatments.

The design of the project is a prospective observational cohort study. A cohort of consecutive ED patients aged 18 or more with an initial pain at triage of 4 or more and discharged from the ED in less than 48 hours with a prescription of opioid will be asked to participate in the study. Patients will be excluded if there is ongoing treatment for a pre-existing chronic pain condition or if they used opioid drugs in the past year. Research nurses will contact the patients by phone at three follow-up time points (1 week, 1 month, and 3 months). Follow-up phone interviews will evaluate pain intensity as well as pain treatment satisfaction (0-10 NRS), monitor adverse events, and investigate possible opioids addiction (SOWS: subjective opioid withdrawal scale). During these interviews, the nurses will also question the patients about their daily opioids usage and if they were relieved from pain.

This study will provide the base for future guidelines regarding the prescription of opioids treatment for specific pathology encountered in ED. It will also give indications on how to adjust the treatments according to adverse events and the level of addiction experienced by patients.

Publications & conference data

2 peer-reviewed publications reference this trial (live from Europe PMC):

1. Quantity of opioids consumed following an emergency department visit for acute pain: a Canadian prospective cohort study.
   Daoust R, Paquet J, Cournoyer A, Piette É, et al · · 2018 · cited 31× · PMID 30224393 · DOI 10.1136/bmjopen-2018-022649
2. Relationship between acute pain trajectories after an emergency department visit and chronic pain: a Canadian prospective cohort study.
   Daoust R, Paquet J, Cournoyer A, Piette É, et al · · 2020 · cited 25× · PMID 33293313 · DOI 10.1136/bmjopen-2020-040390