NCT02796287

Longitudinal Monitoring of Cerebral Connectivity 3T MRI in Patients With a Transcient Global Amnesia

Terminated NA Last updated 15 February 2019

What this trial tests

NA trial testing achieving a neuropsychological examination in the acute amnesic phase in Amnesia in 1 participant. Terminated before completion.

Timeline

2 September 2015

Primary endpoint
31 December 2018

31 December 2018

Quick facts

Lead sponsor	Fondation Hôpital Saint-Joseph
Phase	NA
Status	Terminated
Study type	INTERVENTIONAL
Allocation	na
Design	single group
Masking	none
Primary purpose	basic science
Enrollment	1
Start date	2 September 2015
Primary completion	31 December 2018
Estimated completion	31 December 2018
Sites	1 location across France

Drugs / interventions tested

• achieving a neuropsychological examination in the acute amnesic phase
• Neurological consultation with neuropsychological evaluation
• MRI — full drug profile →

Conditions studied

• Amnesia — all drugs for Amnesia →

Sponsor

Fondation Hôpital Saint-Joseph — full company profile →

Who can join

18 and older, any sex, with Amnesia. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

The transient global amnesia (IA) is defined clinically as a temporary suspension and isolated from the ante and retrograde memory, totally regressing within 24 hours. The causes of AI remain unknown. The diagnosis of IA is based on consensus clinical criteria including the absence of associated location marks. In clinical practice, the MRI is often performed in conjunction with clinical examination because it ensures the absence of differential diagnoses, including stroke.

The visualization of MRI signal abnormalities related to AI directly dependent on the completion time of the review in relation to the onset of symptoms. Typically, no signal abnormality is visible in the hyperacute phase (ie D0-D1) while punctate appear hyperintense on diffusion sequences in hippocampal structures from J2 to J7 to disappear completely. It has been previously demonstrated that the use of higher values of b and / or a better spatial resolution significantly increases the sensitivity of the broadcasting sequence for the detection of these abnormalities hippocampal signal. At St. Joseph Hospital, Investigators explore the AI suspected patients with diffusion tensor sequence (DTI) on our high resolution 3T MRI.

Compared to the classical diffusion sequence, DTI is characterized by the use of a greater number of directions in which the diffusion gradients are applied. One advantage of this technique is to be able to perform tractography of white matter fibers. Thus the "connectome" is a new technique for post-processing of DTI images based tractography and to assess all the networks of nerve fibers in the brain. By this technique, the values of average diffusivity (MD) and fractional anisotropy (FA) can be measured along each of the studied nerve fibers. Group studies thus become feasible to compare quantitatively healthy subjects and patients groups in terms of structural differences within the connectome. The contribution of this technique was recently highlighted in patients with temporal lobe epilepsy.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.