NCT02786420: PARENTs

Imaging Innovations for Placental Assessment in Response to Environmental Pollution (PARENTs)

Completed Last updated 4 May 2021

What this trial tests

trial in Placental Disease in 199 participants. Completed in 3 October 2020.

Timeline

2 October 2015

Primary endpoint
3 June 2020

3 October 2020

Quick facts

Lead sponsor	University of California, Los Angeles
Status	Completed
Study type	OBSERVATIONAL
Enrollment	199
Start date	2 October 2015
Primary completion	3 June 2020
Estimated completion	3 October 2020
Sites	1 location across United States

Conditions studied

• Placental Disease — all drugs for Placental Disease →

Sponsor

University of California, Los Angeles

Who can join

18 and older, female only, with Placental Disease. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

How environmental pollution contributes to poor pregnancy outcome is poorly understood. The first trimester of pregnancy is a particularly vulnerable time period for the developing fetus and a mother's exposure to air pollution may alter the way that the placenta is established and how it functions throughout the rest of pregnancy. This project aims to expand and develop new MRI technologies to assess real-time placental structure and function as pregnancy develops from the first to the third trimester so that early detection, prevention strategies, and early treatment of placental dysfunction as a result of pollution exposures may be developed.

Publications & conference data

6 peer-reviewed publications reference this trial (live from Europe PMC):

1. Cell-free DNA Methylation and Transcriptomic Signature Prediction of Pregnancies with Adverse Outcomes.
   Del Vecchio G, Li Q, Li W, Thamotharan S, et al · · 2021 · cited 55× · PMID 33045922 · DOI 10.1080/15592294.2020.1816774
2. Circulating extracellular vesicles exhibit a differential miRNA profile in gestational diabetes mellitus pregnancies.
   Thamotharan S, Ghosh S, James-Allan L, Lei MYY, et al · · 2022 · cited 20× · PMID 35613088 · DOI 10.1371/journal.pone.0267564
3. Circulating extracellular vesicular microRNA signatures in early gestation show an association with subsequent clinical features of pre-eclampsia.
   Ghosh S, Thamotharan S, Fong J, Lei MYY, et al · · 2024 · cited 18× · PMID 39039088 · DOI 10.1038/s41598-024-64057-w
4. A Description of the Imaging Innovations for Placental Assessment in Response to Environmental Pollution Study.
   Janzen C, Lei MYY, Lee BR, Vangala S, et al · · 2024 · cited 11× · PMID 36241211 · DOI 10.1055/a-1961-2059
5. Early pregnancy imaging predicts ischemic placental disease.
   Lee B, Janzen C, Aliabadi AR, Lei MYY, et al · · 2023 · cited 4× · PMID 37549442 · DOI 10.1016/j.placenta.2023.07.297
6. Association between MRI-derived early second trimester placental physiology and birth weight percentiles in pregnancies without ischemic placenta disease (IPD).
   Ramirez RO, Kim JJ, Fortes PA, Janzen C, et al · · 2025 · PMID 41223521 · DOI 10.1016/j.placenta.2025.11.003