NCT02785315

Cognitive Intervention for Persons With Amnestic Mild Cognitive Impairment

Completed NA Last updated 14 March 2019

What this trial tests

NA trial testing rehabilitation & remediation approach in Mild Cognitive Impairment in 40 participants. Completed in 14 November 2017.

Timeline

16 December 2014

Primary endpoint
14 November 2017

14 November 2017

Quick facts

Lead sponsor	National Taiwan University Hospital
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	single
Primary purpose	health services research
Enrollment	40
Start date	16 December 2014
Primary completion	14 November 2017
Estimated completion	14 November 2017
Sites	1 location across Taiwan

Drugs / interventions tested

• rehabilitation & remediation approach
• remediation approach

Conditions studied

• Mild Cognitive Impairment — all drugs for Mild Cognitive Impairment →

Sponsor

National Taiwan University Hospital

Who can join

50 and older, any sex, with Mild Cognitive Impairment. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

People with mild cognitive impairment (MCI) are at a greater risk of developing dementia. Therefore, it is important to develop effective non-pharmacological interventions to facilitate their cognitive and activities of daily living (ADL) function, which will also prevent or delay their progression to dementia and reduce associated healthcare and social costs. There are currently a variety of cognitive interventions, mainly categorized as remediation and rehabilitation approach. Research to compare their contents and effectiveness is strongly needed. The information can be used to individualize cognitive intervention based on specific cognitive profile of the patient.

This study aims to determine the immediate and long-term efficacy of the remediation approach and rehabilitation approach in enhancing the cognitive and ADL function. The research questions include 1) whether the rehabilitation approach compared with the remediation approach has better effects on improving ADL function; (2) whether the remediation approach may only enhance the performance on the cognitive tests rather than on the ADL function. This study will also explore whether the attitudes of caregivers on providing ADL assistance affect effects of cognitive intervention.

Publications & conference data

4 peer-reviewed publications reference this trial (live from Europe PMC):

1. Computerised cognitive training for preventing dementia in people with mild cognitive impairment.
   Gates NJ, Vernooij RW, Di Nisio M, Karim S, et al · · 2019 · cited 97× · PMID 30864747 · DOI 10.1002/14651858.cd012279.pub2
2. Computerised cognitive training for 12 or more weeks for maintaining cognitive function in cognitively healthy people in late life.
   Gates NJ, Rutjes AW, Di Nisio M, Karim S, et al · · 2020 · cited 53× · PMID 32104914 · DOI 10.1002/14651858.cd012277.pub3
3. Computerised cognitive training for maintaining cognitive function in cognitively healthy people in late life.
   Gates NJ, Rutjes AW, Di Nisio M, Karim S, et al · · 2019 · cited 38× · PMID 30864187 · DOI 10.1002/14651858.cd012277.pub2
4. Computerised cognitive training for maintaining cognitive function in cognitively healthy people in midlife.
   Gates NJ, Rutjes AW, Di Nisio M, Karim S, et al · · 2019 · cited 25× · PMID 30864746 · DOI 10.1002/14651858.cd012278.pub2