NCT02776514 (KIT) is a Phase 2 clinical trial of Triamcort in Osteoarthritis, Knee, sponsored by Balgrist University Hospital.

Who is sponsoring NCT02776514?

NCT02776514 is sponsored by Balgrist University Hospital.

What drugs are being tested in NCT02776514?

Interventions in NCT02776514: Triamcort, Platelet-rich-plasma, Suplasyn1, Placebo.

What condition does NCT02776514 study?

NCT02776514 studies Osteoarthritis, Knee.

Is NCT02776514 still recruiting?

NCT02776514 is currently completed. Last updated 27 January 2022.

Last reviewed 2022-01-27 · How we verify

NCT02776514: KIT

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Intraarticular Injections of Steroids, Hyaluronic Acid or Platelet Rich Plasma Versus Placebo for the Knee Osteoarthritis

Completed Phase 2 Last updated 27 January 2022

What this trial tests

Phase 2 trial testing Triamcort in Osteoarthritis, Knee in 120 participants. Completed in 1 November 2020.

Timeline

1 February 2016

Primary endpoint
1 November 2020

1 November 2020

Quick facts

Lead sponsor	Balgrist University Hospital
Phase	Phase 2
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	120
Start date	1 February 2016
Primary completion	1 November 2020
Estimated completion	1 November 2020
Sites	1 location across Switzerland

Drugs / interventions tested

Triamcort — full drug profile →
Platelet-rich-plasma
Suplasyn1 — full drug profile →
Placebo

Conditions studied

Osteoarthritis, Knee — all drugs for Osteoarthritis, Knee →

Sponsor

Balgrist University Hospital

Who can join

18 and older, any sex, with Osteoarthritis, Knee. Patients with the condition only — healthy volunteers not accepted.

What's being measured

Primary outcomes are the specific endpoints the trial is designed to prove or disprove.

Pain assessment
Time frame: up to 24 months after injection
numeric rating scale (NRS) and WOMAC
Magnetic Resonance imaging
Time frame: up to 12 months after injection
cartilage volume (ml)
Magnetic Resonance imaging
Time frame: up to 12 months after injection
T2-values in cartilage (mean Signal +/- Standard Deviation) in subregions

Sponsor's own description

This study investigates clinical outcome and imaging outcome parameters after intraarticular injection of steroids, platelet-rich-plasma (prp), hyaluronic acid or placebo in patients with early osteoarthritis of the knee joint.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

Molecular Classification of Knee Osteoarthritis.
Lv Z, Yang YX, Li J, Fei Y, et al · · 2021 · cited 69× · PMID 34513847 · DOI 10.3389/fcell.2021.725568
A Randomized Trial of Intra-articular Injection Therapy for Knee Osteoarthritis.
Tschopp M, Pfirrmann CWA, Fucentese SF, Brunner F, et al · · 2023 · cited 42× · PMID 36728848 · DOI 10.1097/rli.0000000000000942
Challenges and opportunities of pharmacological interventions for osteoarthritis: A review of current clinical trials and developments.
Vrouwe JPM, Burggraaf J, Kloppenburg M, Stuurman FE. · · 2021 · cited 16× · PMID 36474768 · DOI 10.1016/j.ocarto.2021.100212

Verify or expand the search:

Other recruiting trials for Osteoarthritis, Knee

Currently open trials in the same condition.

NCT07509307 — AMAZE 6: A Research Study Investigating How Well the Medicine NNC0487-0111 Helps People With Excess Body Weight and Knee · Phase 3 · recruiting
NCT06488144 — Rehabilitation for Arthritis of The Knee: mainTaining Improvement for Veterans · Phase 3 · recruiting
NCT07386561 — Virtual Reality Therapy and Non-Sleep Deep Rest Relaxation After Joint Arthroplasty · NA · active not recruiting
NCT07514598 — Effect of J-Shaped Incision After Total Knee Arthroplasty (J-TKA) · NA · active not recruiting
NCT07058623 — Nurse-Led Telehealth vs In-Person Follow-Up After Total Knee Replacement · NA · recruiting

Other Balgrist University Hospital trials

Trials by the same sponsor.

NCT06813859 — Monitored Effects of Physical Activity on Fetal Heart Rate by Using a Wireless Non-invasive Device · not yet recruiting
NCT06668116 — The Impact of Local Anesthetic Dilution on Possible Blinding for Nerve Blocks · NA · completed
NCT06552195 — Augmented Reality in Learning Anatomy: The TEACHANATOMY Randomized Cross-over Trial · NA · not yet recruiting
NCT06443879 — Loss and Return of Sensation After Axillary Brachial Plexus Nerve Block - Distally or Proximally · completed
NCT06036849 — Linking Physiological Responses to Clinical Outcomes Following Cervical Spine Manipulation · NA · completed

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02776514 (US National Library of Medicine, public domain)
Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Balgrist University Hospital
Last refreshed: 27 January 2022

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02776514.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing