Who is sponsoring NCT02772367?

NCT02772367 is sponsored by Memorial Sloan Kettering Cancer Center.

What condition does NCT02772367 study?

NCT02772367 studies Breast Cancer.

What drugs are being tested in NCT02772367?

Interventions: skin punch biopsy.

What is the status of NCT02772367?

NCT02772367 is currently RECRUITING.

Last reviewed 2025-07-14 · How we verify

Generation of Induced Pluripotent Stem Cell Derived Cardiomyocytes From Patients Exposed to Trastuzumab Therapy for Breast Cancer

NCT02772367 RECRUITING

The purpose of this study is to investigate whether cells from a biopsy taken from the patient skin can be transformed into cardiomyocytes the changes in cardiomyocyte (heart muscle cells) when grown in a special culture medium outside of the body. The structure and function of these cells will then be studied to determine why some patients with breast cancer who are treated with chemotherapy including anthracycline (e.g. Doxorubicin) and anti-HER2 therapy (e.g. Herceptin) develop decreased heart function.

Details

Lead sponsor	Memorial Sloan Kettering Cancer Center
Status	RECRUITING
Enrolment	120
Start date	2016-05-11
Completion	2026-05

Conditions

Breast Cancer

Interventions

skin punch biopsy

Primary outcomes

derive iPSs from skin fibroblasts — 1 day
described by Yamanaka et al with modification using the Millipore STEMCCA excisable polycystronic lentivirus reprogramming kit.2

Countries

United States