Last reviewed · How we verify
NCT02759965
Neuroinflammation and Cognitive Dysfunction After Orthopedic Surgery
trial in Surgery in 34 participants. Completed in 31 December 2018.
30 March 2016
Quick facts
| Lead sponsor | Karolinska University Hospital |
|---|---|
| Status | Completed |
| Study type | OBSERVATIONAL |
| Enrollment | 34 |
| Start date | 1 September 2014 |
| Primary completion | 30 March 2016 |
| Estimated completion | 31 December 2018 |
| Sites | 2 locations across Sweden |
Conditions studied
- Surgery — all drugs for Surgery →
- Acute Phase Reaction — all drugs for Acute Phase Reaction →
Sponsor
Karolinska University Hospital
Who can join
Adults 50 to 85, male only, with Surgery or Acute Phase Reaction. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
The primary hypothesis that orthopaedic surgery induces a neuroinflammatory response within 48 hours after elective hip or knee surgery and that there is an association between exaggerated CNS inflammatory response or impaired inflammatory resolution and postoperative cognitive dysfunction within one week and at three months postoperatively.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Changes in circulating extracellular vesicle cargo are associated with cognitive decline after major surgery: an observational case-control study.
Mkrtchian S, Eldh M, Ebberyd A, Gabrielsson S, et al · · 2025 · cited 3× · PMID 39426921 · DOI 10.1016/j.bja.2024.07.040
Verify or expand the search:
- PubMed search for NCT02759965
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
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Other Karolinska University Hospital trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02759965 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Karolinska University Hospital
- Last refreshed: 16 April 2019
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02759965.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing