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NCT02756715
The Effect of Anesthetics Agents on Vascular Injury and Level of Syndecan-1 During Knee Surgery
NA trial testing propofol group in Ischemia in 80 participants. Completed in 27 February 2020.
26 March 2018
Quick facts
| Lead sponsor | Konkuk University Medical Center |
|---|---|
| Phase | NA |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | single |
| Primary purpose | basic science |
| Enrollment | 80 |
| Start date | 30 May 2016 |
| Primary completion | 26 March 2018 |
| Estimated completion | 27 February 2020 |
| Sites | 1 location across South Korea |
Drugs / interventions tested
- propofol group
- Desflurane group — full drug profile →
Conditions studied
- Ischemia — all drugs for Ischemia →
Sponsor
Konkuk University Medical Center
Who can join
20 and older, any sex, with Ischemia. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Ischeic reperfusion injury lead to a cellular dyfunction and increase in soluble glycocalyx of blood flow. syndecan-1 was a marker of glycocalyx. The purpose of this study is to prove the variation of level of serum syndecan-1 between preoperative and postoperative period.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Impact of Anesthetic Agents on Endothelial Glycocalyx Injury during Total Knee Arthroplasty: Desflurane- vs. Propofol-Based Anesthesia-A Prospective Randomized Controlled Trial.
Oh CS, Choi JM, Park EH, Piao L, et al · · 2021 · cited 3× · PMID 33564684 · DOI 10.1155/2021/8880267
Verify or expand the search:
- PubMed search for NCT02756715
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of propofol group
Trials testing the same drug.
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- NCT05322902 — Remimazolam Total Intravenous Anesthesia Under Analgesia Nociception Index-guidance · NA · completed
- NCT05164159 — The Comparison of Hemodynamic Effects Between Remimazolam-remifentanil and Propofol-remifentanil in Patients Undergoing · NA · completed
Other recruiting trials for Ischemia
Currently open trials in the same condition.
- NCT06954610 — Cardiac Assessment for Recurrent Stroke Risk Evaluation in Atrial Fibrillation · recruiting
- NCT05487820 — Detecting Tissue Ischemia in Reconstruction Flaps by a Novel CO2 Biosensor (DIMENSION-study) · NA · recruiting
- NCT05297266 — Early Discovery of Ischemia After Replantation Surgery of the Extremities · NA · recruiting
- NCT05333068 — COMBINE-INTERVENE: COMBINEd Ischemia and Vulnerable Plaque Percutaneous INTERVENtion to Reduce Cardiovascular Events · NA · active not recruiting
- NCT04924985 — Goal-directed CPR Using Cerebral Oximetry · NA · active not recruiting
Other Konkuk University Medical Center trials
Trials by the same sponsor.
- NCT06637943 — Comparison of the Diagnosis Time of VET and SCL in Patients With Intraoperative Coagulopathy · not yet recruiting
- NCT06144112 — Fibrinogen Concentrates Versus Cryoprecipitate in Liver Transplant Surgery · Phase 4 · not yet recruiting
- NCT06664320 — Mild ANH on Pre-bypass Coagulation Function During Cardiac Surgery · NA · not yet recruiting
- NCT06574594 — Effect of MTX Discontinuation on Shingrix Response in RA · NA · recruiting
- NCT06144099 — Prothrombin Complex Concentrate vs Fresh Frozen Plasma in Goal-directed Bleeding Management in Non-cardiac Surgery · Phase 4 · unknown
Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02756715 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 9 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by Konkuk University Medical Center
- Last refreshed: 28 February 2020
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02756715.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing