NCT02756312

The Impact of Anesthesia on High- Grade Glioma Patients

Status unknown NA Last updated 9 September 2020

What this trial tests

NA trial testing IV Anesthesia in Anesthesia, Outcome, High-grade Glioma in 196 participants. Status unknown.

Timeline

1 October 2020

Primary endpoint
31 December 2022

31 December 2022

Quick facts

Lead sponsor	Beijing Tiantan Hospital
Phase	NA
Status	Status unknown
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	triple
Primary purpose	treatment
Enrollment	196
Start date	1 October 2020
Primary completion	31 December 2022
Estimated completion	31 December 2022
Sites	1 location across China

Drugs / interventions tested

• IV Anesthesia
• IH anesthesia

Conditions studied

• Anesthesia, Outcome, High-grade Glioma — all drugs for Anesthesia, Outcome, High-grade Glioma →

Sponsor

Beijing Tiantan Hospital

Who can join

Adults 18 to 80, any sex, with Anesthesia, Outcome, High-grade Glioma. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Although bench data and retrospective studies have provided a promising picture of the possible influence of anesthetic technique on the risk of tumor progression and patients mortality, current evidence from RCTs is inadequate to show whether the type of anesthetics might influence tumor progression and patient survival.There are many thousands of patients with a cancer diagnosis undergoing surgery every year, and in the context of biological plausibility, it should lead to the urgent undertaking of RCTs to further evaluate the association between the anesthetic management and patient outcome.

Publications & conference data

3 peer-reviewed publications reference this trial (live from Europe PMC):

1. Long-term prognosis after cancer surgery with inhalational anesthesia and total intravenous anesthesia: a systematic review and meta-analysis.
   Jin Z, Li R, Liu J, Lin J. · · 2019 · cited 31× · PMID 31333811
2. Effect of anesthesia on the outcome of high-grade glioma patients undergoing supratentorial resection: study protocol for a pragmatic randomized controlled trial.
   Dong J, Wang D, Sun H, Zeng M, et al · · 2022 · cited 1× · PMID 36167574 · DOI 10.1186/s13063-022-06716-9
3. Effect of Anesthesia on The Outcome of High-Grade Glioma Patients Undergoing Supratentorial Resection: Study Protocol for A Randomized Controlled Trial 
   Wang D, Dong J, Zeng M, Liu X, et al · · 2021 · DOI 10.21203/rs.3.rs-290224/v1