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NCT02748382: FISSH
Fluids in Sepsis and Septic Shock
Phase 2, PHASE3 trial testing higher chloride crystalloid in Sepsis in 50 participants. Completed in 19 August 2017.
19 August 2017
Quick facts
| Lead sponsor | McMaster University |
|---|---|
| Phase | Phase 2, PHASE3 |
| Status | Completed |
| Study type | INTERVENTIONAL |
| Allocation | randomized |
| Design | parallel |
| Masking | quadruple |
| Primary purpose | treatment |
| Enrollment | 50 |
| Start date | 18 August 2016 |
| Primary completion | 19 August 2017 |
| Estimated completion | 19 August 2017 |
| Sites | 2 locations across Canada |
Drugs / interventions tested
- higher chloride crystalloid
- higher chloride albumin
- lower chloride crystalloid
- lower chloride albumin
Conditions studied
- Sepsis — all drugs for Sepsis →
- Septic Shock — all drugs for Septic Shock →
Sponsor
McMaster University
Who can join
16 and older, any sex, with Sepsis or Septic Shock. Patients with the condition only — healthy volunteers not accepted.
Sponsor's own description
Despite evidence of the physiologic benefits and possible lower mortality associated with low chloride solutions, normal saline remains the most wildly used fluid in the world. Given uncertainty about the impact of lower chloride versus higher chloride solutions on mortality, it is unlikely that clinical practice will change without new and direct RCT evidence. Editorials published in leading critical care journals have called for RCT's to address this important clinical question. The proposed feasibility RCT will investigate the feasibility of a large-scale trial directly comparing low chloride versus normal chloride for resuscitation in septic shock on patient-important outcomes such as mortality and AKI.
Publications & conference data
1 peer-reviewed publication reference this trial (live from Europe PMC):
-
Fluids in Sepsis and Septic Shock (FISSH): protocol for a pilot randomised controlled trial.
Rochwerg B, Millen T, Austin P, Zeller M, et al · · 2017 · cited 12× · PMID 28729329 · DOI 10.1136/bmjopen-2017-017602
Verify or expand the search:
- PubMed search for NCT02748382
- Europe PMC full search
- ASCO Meeting Library
- ESMO Meeting Library
- bioRxiv preprints
- medRxiv preprints
- Google Scholar
Related trials
Other trials of higher chloride crystalloid
Trials testing the same drug.
- NCT03677102 — Fluids in Septic Shock (FISSH) · Phase 2, PHASE3 · completed
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Currently open trials in the same condition.
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Other McMaster University trials
Trials by the same sponsor.
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Verify against primary sources
- ClinicalTrials.gov — authoritative US registry record
- WHO ICTRP — international registry index
- EU Clinical Trials Register
- Sponsor press releases (Google)
- Trial protocol + status: ClinicalTrials.gov NCT02748382 (US National Library of Medicine, public domain)
- Publications: Europe PMC API search by NCT ID, retrieved 10 June 2026
- Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
- Sponsor: as reported to ClinicalTrials.gov by McMaster University
- Last refreshed: 29 August 2018
Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02748382.
Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing