A Pilot Study of the Effects of Nebulized Epoprostenol (Flolan) and Systemic Phenylephrine on Arterial Oxygenation During One Lung Ventilation (FLOLAN)

NCT02748265 Phase 4 COMPLETED

This is a pilot study of a new use of Epoprostenol via inhalation (Epoprostenol is approved for intravenous use). The purpose of this study is to administered inhaled Epoprostenol and intravenous Phenylephrine to improve arterial oxygen tension during one-lung anesthesia either with volatile anesthesia (Sevoflurane) or with intravenous anesthesia (Propofol).

Details

Lead sponsor	University Health Network, Toronto
Phase	Phase 4
Status	COMPLETED
Enrolment	8
Start date	2016-03
Completion	2018-12-31

Conditions

• Oxygenation During One Lung Ventilation

Interventions

• Inhaled Epoprostenol and phenylephrine
• Sevoflurane
• Propofol

Primary outcomes

• Increase of arterial oxygen tension in mmHg, during one-lung ventilation surgery, in response to combined nebulized epoprostenol/phenylephrine treatment — Changes measured during surgery, from start of treatment at 30 minutes after one-lung ventilation (T30) to end of the 30 minutes treatment (T60).

Countries

Canada