NCT02748109

Assessment and Rehabilitation of Central Sensory Impairments for Balance in mTBI

Completed NA Last updated 6 June 2025

What this trial tests

NA trial testing Vestibular Rehabilitation + audio biofeedback in Brain Injury in 132 participants. Completed in 24 June 2019.

Timeline

11 May 2016

Primary endpoint
11 April 2019

24 June 2019

Quick facts

Lead sponsor	Oregon Health and Science University
Phase	NA
Status	Completed
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	none
Primary purpose	treatment
Enrollment	132
Start date	11 May 2016
Primary completion	11 April 2019
Estimated completion	24 June 2019
Sites	1 location across United States

Drugs / interventions tested

• Vestibular Rehabilitation + audio biofeedback
• Vestibular Rehabilitation

Conditions studied

• Brain Injury — all drugs for Brain Injury →

Sponsor

Oregon Health and Science University

Who can join

Adults 18 to 60, any sex, with Brain Injury. Patients with the condition only — healthy volunteers not accepted.

Sponsor's own description

Our central hypothesis is that chronic balance deficits after mild traumatic brain injury (mTBI) result from impairments in central sensorimotor integration (CSMI) that may be helped by rehabilitation. There are two objectives of this proposal; the first objective is to characterize balance deficits in people with mTBI. The second objective is to use a novel auditory bio-feedback (ABF) device to improve measures central sensorimotor integration and balance control.

Publications & conference data

8 peer-reviewed publications reference this trial (live from Europe PMC):

1. Inertial Sensor-Based Assessment of Central Sensory Integration for Balance After Mild Traumatic Brain Injury.
   Gera G, Chesnutt J, Mancini M, Horak FB, et al · · 2018 · cited 38× · PMID 29635623 · DOI 10.1093/milmed/usx162
2. Assessment and rehabilitation of central sensory impairments for balance in mTBI using auditory biofeedback: a randomized clinical trial.
   Fino PC, Peterka RJ, Hullar TE, Murchison C, et al · · 2017 · cited 33× · PMID 28231824 · DOI 10.1186/s12883-017-0812-7
3. Exploring persistent complaints of imbalance after mTBI: Oculomotor, peripheral vestibular and central sensory integration function.
   Campbell KR, Parrington L, Peterka RJ, Martini DN, et al · · 2021 · cited 23× · PMID 34024798 · DOI 10.3233/ves-201590
4. Head stabilization during standing in people with persisting symptoms after mild traumatic brain injury.
   Fino PC, Raffegeau TE, Parrington L, Peterka RJ, et al · · 2020 · cited 21× · PMID 33011672 · DOI 10.1016/j.jbiomech.2020.110045
5. Central sensorimotor integration assessment reveals deficits in standing balance control in people with chronic mild traumatic brain injury.
   Campbell KR, King LA, Parrington L, Fino PC, et al · · 2022 · cited 17× · PMID 36341095 · DOI 10.3389/fneur.2022.897454
6. Prefrontal Cortex Activity During Gait in People With Persistent Symptoms After Concussion.
   Martini DN, Mancini M, Antonellis P, McDonnell P, et al · · 2024 · cited 10× · PMID 38506532 · DOI 10.1177/15459683241240423
7. Symptoms and Central Sensory Integration in People With Chronic mTBI: Clinical Implications.
   Martini DN, Gera G, Brumbach BH, Campbell KR, et al · · 2023 · cited 7× · PMID 35657326 · DOI 10.1093/milmed/usac157
8. The effects of augmenting traditional rehabilitation with audio biofeedback in people with persistent imbalance following mild traumatic brain injury.
   Campbell KR, Peterka RJ, Fino PC, Parrington L, et al · · 2022 · cited 5× · PMID 36267889 · DOI 10.3389/fneur.2022.926691