NCT02746263 is a Phase 4 clinical trial of IV acetaminophen in Acute Pain, Postoperative, sponsored by Mallinckrodt.

Who is sponsoring NCT02746263?

NCT02746263 is sponsored by Mallinckrodt.

What drugs are being tested in NCT02746263?

Interventions in NCT02746263: IV acetaminophen, Oral acetaminophen, Morphine.

What condition does NCT02746263 study?

NCT02746263 studies Acute Pain, Postoperative.

Is NCT02746263 still recruiting?

NCT02746263 is currently terminated. Last updated 19 November 2019.

Are results published for NCT02746263?

Yes — primary outcome results have been posted to ClinicalTrials.gov. See the outcomes section above for details.

Last reviewed 2019-11-19 · How we verify

NCT02746263

Name: Drug Landscape Pharmaceutical Database
Creator: Drug Landscape
Published: 2026-01-01
License: https://creativecommons.org/licenses/by/4.0/

Multicenter Study to Compare Intravenous and Oral Acetaminophen for the Treatment of Acute Moderate to Severe Pain

Terminated Phase 4 Results posted Last updated 19 November 2019

What this trial tests

Phase 4 trial testing IV acetaminophen in Acute Pain, Postoperative in 1 participant. Terminated before completion.

Timeline

27 April 2016

Primary endpoint
5 May 2016

5 May 2016

Quick facts

Lead sponsor	Mallinckrodt
Phase	Phase 4
Status	Terminated
Study type	INTERVENTIONAL
Allocation	randomized
Design	parallel
Masking	double
Primary purpose	treatment
Enrollment	1
Start date	27 April 2016
Primary completion	5 May 2016
Estimated completion	5 May 2016
Sites	2 locations across United States

Drugs / interventions tested

IV acetaminophen — full drug profile →
Oral acetaminophen
Morphine

Conditions studied

Acute Pain, Postoperative — all drugs for Acute Pain, Postoperative →

Sponsor

Mallinckrodt — full company profile →

Who can join

Adults 50 to 90, any sex, with Acute Pain, Postoperative. Patients with the condition only — healthy volunteers not accepted.

Adverse events — posted to ClinicalTrials.gov

Time frame: 9 days. Reporting threshold: 0%. Adverse-event reports describe events observed during the trial — not all are caused by the drug.

IV Acetaminophen/Morphine

Serious: 0

Deaths: 0

Oral Acetaminophen/Morphine

Serious: 0/1 (0%)

Deaths: 0/1

Other adverse events (9 terms — click to expand)

Reaction	System	IV Acetaminophen/Morphine	Oral Acetaminophen/Morphine
Acute blood loss anemia	Blood and lymphatic system disorders	—	—
Diffuse bronchial wall thickening	Respiratory, thoracic and mediastinal disorders	—	—
Intermittent thrombocytopenia	Blood and lymphatic system disorders	—	—
Intermittent leucocytosis	Blood and lymphatic system disorders	—	—
Persistent sinus tachycardia	Cardiac disorders	—	—
Postoperative pain	General disorders	—	—
Pulmonary hypertension	Respiratory, thoracic and mediastinal disorders	—	—
Stress hyperglycemia	Endocrine disorders	—	—
Suspicion of adrenal insufficiency	Endocrine disorders	—	—

Data from ClinicalTrials.gov NCT02746263 adverse events section.

Sponsor's own description

The purpose of this study is to compare intravenous (IV) and oral acetaminophen for the treatment of acute moderate to severe pain in combination with standard patient-controlled analgesia (PCA) in adult subjects following total knee replacement.

Publications & conference data

No peer-reviewed publications indexed yet for this trial.

Verify or expand the search:

Other trials of IV acetaminophen

Trials testing the same drug.

NCT04933058 — Opioid Based Analgesia vs Non-opioid Analgesia for Oocyte Retrieval Procedure · NA · completed
NCT04093219 — PANDORA: Delirium Prevention After Cardiac Surgery Using IV Acetaminophen to Prevent Postoperative Delirium in Older Car · Phase 3 · completed
NCT03553498 — IV Acetaminophen as Adjuvant Analgesic to Hydromorphone - Emergency Department Patients · Phase 3 · completed
NCT03062488 — Emergence Agitation and Pain Scores in Pediatrics When Comparing Single-modal vs Multi-modal Analgesia for ENT Surgery · EARLY_PHASE1 · completed
NCT02549716 — Clinical, Pharmacological and Molecular Effects of IV and Oral Acetaminophen in Adults With aSAH · Phase 4 · terminated

Other recruiting trials for Acute Pain, Postoperative

Currently open trials in the same condition.

NCT07336264 — Characterization of Acute Pain · recruiting

Other Mallinckrodt trials

Trials by the same sponsor.

NCT04169061 — Impact of Acthar on Everyday Life of Participants With Severe Keratitis · Phase 4 · completed
NCT03712280 — MNK6106 for Liver Disease (Hepatic Cirrhosis) That in the Past Has Affected the Brain (Hepatic Encephalopathy) · Phase 2 · completed
NCT03656692 — Safety and Effectiveness of Acthar Gel for Inflammation of the Eye's Uvea (Middle Layer) · Phase 4 · terminated
NCT03320070 — Acthar Gel in Participants With Pulmonary Sarcoidosis · Phase 4 · completed
NCT03132428 — Registry to Evaluate INOmax in Newborn Babies With Pulmonary Hypertension · terminated

Verify against primary sources

ClinicalTrials.gov — authoritative US registry record
WHO ICTRP — international registry index
EU Clinical Trials Register
Sponsor press releases (Google)

Data sources for this page

Trial protocol + status: ClinicalTrials.gov NCT02746263 (US National Library of Medicine, public domain)
Drug + disease cross-links: matched in real time against Drug Landscape's normalised drug + company + condition tables
Sponsor: as reported to ClinicalTrials.gov by Mallinckrodt
Last refreshed: 19 November 2019

Drug Landscape aggregates and links these public records for informational use only. Always verify against the primary source before clinical or regulatory decisions. Canonical URL: https://druglandscape.com/trial/NCT02746263.

Primary sources · FDA · ClinicalTrials.gov · EMA · SEC EDGAR · ChEMBL · Wikidata · full sourcing