Chronic Metformin Treatment Induces a Dietary Restriction-like State in Overweight Human

NCT02745886 Phase 4 UNKNOWN

The fact that metformin treatment has been associated with reduced risk of cancer and cardiovascular disease raises the possibility of a beneficial role of metformin for other age-related diseases. The actions of metformin resemble the effects of calorie restriction (CR) to some extent, and microarray analyses have shown that metformin induces a gene expression profile that aligns with that of CR in animal. The aim of the study is to investigate whether metformin treatment can induce dietary restriction-like state in human. Sixty overweight subjects will be included in this study, and participants will be divided 3 groups (20 cases in each group)including metformin group (0.85, twice daily), standard diet group, and CR group. All subjects will be treated 6 months. At the end of this study, blood samples and muscle samples will be obtained.

Details

Lead sponsor	Xiang Guang-da
Phase	Phase 4
Status	UNKNOWN
Enrolment	60
Start date	2016-04
Completion	2016-12

Conditions

• Overweight Subjects
• Metformin
• Aging

Interventions

• metformin 0.85 twice daily for 6 months
• Calorie restriction

Primary outcomes

• The differences of gene expression profile among 3 groups. — 6 months
  The gene expression profile will be checked by microarray, and compared the number differences of pathways among 3 groups.

Countries

China