Physiologic Study of Cerebral Perfusion

NCT02744625 Phase 4 COMPLETED

The aim of the study is to measure cerebral perfusion using MRI in healthy subjects (with and without sedation) and in vasopressor-dependent patients

Details

Lead sponsor	Centre de recherche du Centre hospitalier universitaire de Sherbrooke
Phase	Phase 4
Status	COMPLETED
Enrolment	22
Start date	2016-04
Completion	2017-03

Conditions

• Cerebral Perfusion Pressure
• Vasopressor Agents
• Shock
• Magnetic Resonance Imaging (MRI), Functional

Interventions

• Higher doses of vasopressor therapy for a MAP of 75 mmHg
• Lower doses of vasopressor therapy for a MAP of 65 mmHg
• Propofol for light sedation

Primary outcomes

• Global and regional cerebral blood flow — Within 15 minutes of intervention initiation
  Cerebral blood flow will be measured by the arterial spin labeling technique (ASL) which provides information expressed in mL/100g/min. Using 3-T MRI technology,we will first acquire T1 images of the brain and sub-regions of interest. Thereafter, ASL sequences will be acquired in contiguous slices. The procedure will be followed on sedation and off sedation for healthy volunteers (in random order) and at mean arterial pressure of 65 mmHg and 75 mmHg (in random order) in patients receiving vasopressor therapy.

Countries

Canada